Nitrogen and/or sulfur containing heterocyclic azo dyes with aniline, tetrahydroquinoline and benzomorpholine couplers having sulfate group

ABSTRACT

Disclosed are azo dyes prepared by diazotizing heterocyclic amines such as 2-aminobenzothiazole, 3-amino-2,1-benzisothiazole, 5-amino-1,2,4-thiadiazole, 5-aminoisothiazole, 5-aminopyrazole, 2-aminothiophene and 2-amino-1,3,4-thiadiazole, followed by coupling with certain aniline, tetrahydroquinoline, or benzomorpholine compounds containing sulfate groups. These amines may be substituted with a large variety of groups including lower alkyl, lower alkoxy, cyano, carbamoyl, sulfamoyl, and halogen. These dyes have excellent dyeing properties on polyamide fibers and also impart color to cellulose acetate fibers and wool.

This invention concerns novel dyes which comprise heterocyclic diazomoieties and aromatic amine couplers having sulfate groups. These dyesare substantially water soluble and are particularly useful for dyeingpolyamide, wool and the like and exhibit excellent properties includingfastness to light and dyeability.

The dyes of this invention correspond to the following general formula:##STR1## wherein R is a heterocyclic diazo radical which may besubstituted as further defined below; R₁ is selected from groups such ashydrogen, lower alkyl and lower alkoxy each of which may be substituted,halogen, acylamido, lower alkylthio and aryloxy; R₂ is selected fromhydrogen, lower alkyl which may be substituted, lower alkenyl, aryl orcycloalkyl which also may be substituted, and R₂ may in conjunction withR₁ also form a 1,2,3,4-tetrahydroquinoline or a2,3-dihydro-1,4-benzoxazine (benzomorpholine) ring; Z is a linking groupsuch as lower alkylene; M is H⁺, Na⁺, K⁺, or NH₄ ⁺ ; and m is 0, 1 or 2.The various alkyl, alkylene, alkenyl, alkoxy, alkanoyl and the likegroups within the above definitions may be straight or branched chainand the types and degree of substitutions thereof and also on the cyclicmoieties as further defined below must, of course, be judiciouslyselected as known to those skilled in the art. The term "lower" as usedthroughout the specification and claims denotes 1-6 carbons.

More particularly the dyes correspond to the formula above wherein Rrepresents the following radicals I through VII: ##STR2## In theseformulae, radical I may have 1-3 substituents selected from lower alkyl,lower alkoxy, thiocyano, lower alkylthio, cyano, carbamoyl, loweralkylcarbamoyl, lower alkoxycarbonyl, acyl, lower alkylsulfonyl,sulfamoyl, SO₂ NH(lower alkyl), SO₂ N(di-lower alkyl), loweralkylsulfonamido, acylamido, halogen, trifluoromethyl and SO₃ (aryl);

Radical II may have 1-3 substituents selected from lower alkyl, loweralkoxy, chlorine, bromine, SO₂ NH₂, SO₂ NH(lower alkyl), and SO₂N(di-lower alkyl);

Radical III may have a substituent selected from lower alkyl, loweralkoxy, halogen, lower alkylsulfonyl, SO₂ NH₂, SO₂ NH(lower alkyl), SO₂N(di-lower alkyl), arylsulfonyl, acylamido, aryl, arylthio, loweralkenylthio, cyclohexylthio, thiocyano, cyclohexylsulfonyl, loweralkylthio, and cyclohexyl;

Radical IV may have a substituent selected from lower alkyl, aryl, loweralkylthio, cyclohexylthio, and lower alkylsulfonyl;

Radical V may have 1 or 2 substituents selected from lower alkyl,halogen, cyano, carbamoyl, CONH lower alkyl, alkoxycarbonyl, loweralkylthio, lower alkenylthio, arylthio, cyclohexylthio, s-heterocycle,aryloxy, and lower alkoxy;

Radical VI may have 1 or 2 substituents selected from lower alkyl, loweralkoxycarbonyl, lower alkylthio, aryl, cyano, carbamoyl, loweralkylcarbamoyl, and lower alkylsulfonyl, and the hydrogen on the N maybe replaced with lower alkyl, aryl of 6-10 carbons, lower alkylsulfonyl,arylsulfonyl, lower alkanoyl, or lower alkoxycarbonyl; and

Radical VII may be substituted with 1-3 groups selected from loweralkyl, cyano, lower alkoxycarbonyl, acyl, lower alkylsulfonyl,arylsulfonyl, carbamoyl, lower alkylcarbamoyl, aryl, halogen, sulfamoyl,lower alkylsulfamoyl and formyl.

The couplers are described more particularly by the following formulae:##STR3##

In these formulae:

R₁ is selected from hydrogen, lower alkyl, lower alkoxy, halogen,acylamido, lower alkylthio, and aryloxy;

R₂ is selected from hydrogen, aryl, cycloalkyl, and lower alkyl;

R₃ and R₄ are each selected from hydrogen and lower alkyl; m is 0, 1 or2; M is Na⁺, K⁺, H⁺ or NH₄ ⁺ ; Z is selected from straight or branchedchain lower alkylene which may be substituted, for example, with aryl,phenyl, halogen, OSO₃ M, lower alkoxy or aryloxy, --CH₂ (CH₂)_(n) X--CH₂(CH₂)_(p) --, where n is 1, 2 or 3, p is 0, 1, 2 or 3, and X is O, S,SO₂, --SO₂ NH--, --SO₂ N(lower alkyl)--, SO₂ N(aryl) --N(SO₂ aryl)--,--NHCO--, --NHCONH, --N(SO₂ lower alkyl), and --CON(lower alkyl); and inall of the above definitions of groups containing lower alkyl, loweralkylene, or cyclic radicals, such radicals may bear up to threesubstituents selected from hydroxy, lower alkoxy, aryl, aryloxy,cyclohexyl, furyl, lower alkylcyclohexyl, aroyloxy, loweralkoxycarbonyl, lower alkanoyloxy, sulfamoyl, SO₂ NH(aryl), SO.sub. 2NH(lower alkyl), SO₂ N(di-lower alkyl), NHCOO(lower alkyl), NHCONH(loweralkyl), acylamido particularly where the acyl moiety is lower alkanoyl,lower alkylsulfonamido, succinimido, glutarimido, phthalimido,2-pyrrolidono, cyano, carbamoyl, lower alkylcarbamoyl, loweralkoxyalkoxy, lower alkylthio, halogen, arylthio, lower alkylsulfonyland arylsulfonyl.

The dyes of this invention impart orange to blue shades on fibers,particularly polyamides, and are especially useful for dyeing polyamide(nylon) carpets, giving good fastness to light, ozone, oxides ofnitrogen, washing, sublimation, crocking, and the like, and having goodleveling, transfer, exhaustion and build properties.

The heterocyclic amines used in this invention are prepared according toknown procedures. The dyes may be prepared as follows:

Method I

An intermediate coupler containing one or more hydroxy groups may bereacted with sulfuric acid to produce a sulfate ester, which is thencoupled with a diazonium salt to give the dye, as follows: ##STR4##

Method II

An intermediate coupler containing one or more hydroxy groups may becoupled with the diazonium salt and then the dye reacted with sulfuricacid to produce the sulfate ester, as follows: ##STR5##

The dyes may be isolated when M is H⁺, but are usually isolated as thesodium or potassium salts.

The following examples will further illustrate these preparativemethods.

COUPLER PREPARATIONS EXAMPLE 1 Preparation ofN-Ethyl-N-2-sulfatoethyl-m-toluidine

To 75 ml of concentrated sulfuric acid is added 53.8 g. ofN-ethyl-N-2-hydroxyethyl-m-toluidine with stirring, keeping thetemperature below 50° C. The solution is stirred for 2 hrs. and thetemperature allowed to drop. Thin-layer chromatography shows anessentially complete reaction. The viscous reaction mixture is drownedin ice-water and diluted to a total volume of about 900 ml. the couplersolution is then used to prepare the dyes without further treatment.

EXAMPLE 2 Preparation of N-Ethyl-N-2-sulfatoethylaniline

To 25 ml of concentrated sulfuric acid is added 16.5 g. ofN-ethyl-N-2-hydroxyethylaniline at less than 40° C. After stirring 2hrs. and allowing the temperature to drop, the reaction mixture is addedto 200 g. of ice and diluted to a total volume of about 250 ml. Analiquot of this coupler solution is used without further treatment.

EXAMPLE 3 Preparation of 2,7-Dimethyl-N-(2,3-disulfatopropyl)1,2,3,4-tetrahydroquinoline

To 40 g. of concentrated sulfuric acid is added 11.75 g. ofN-(2,3-dihydroxypropyl)-2,7-dimethyl-1,2,3,4-tetrahydroquinoline atabout 50° C. The material is difficult to dissolve and requires stirringfor several hours at room temperature. After solution is completed,stirring is continued for 1 hr. and the solution drowned in 100 g. ice.The solution is used without further treatment to prepare dyes.

EXAMPLE 4 Preparation of N,N-bis(2-Sulfatoethyl)-m-toluidine

N,N-bis(2-Hydroxyethyl)-m-toluidine (1 g.) is added to 3 g. ofconcentrated sulfuric acid, allowed to stand at room temperature, andthe reaction mixture added to 20 g. of ice. The solution is used toprepare dyes.

EXAMPLE 5 Preparation ofN-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline

To 250 ml of concentrated sulfuric acid is added 120 g. ofN-(2-hydroxyethyl)-1,2,3,4-tetrahydro-2,2,4,7-tetramethylquinoline atless than 30° C. The solution is stirred for 2 hrs. and drowned onto1250 g. of ice and water. After stirring for about 30 min., the whitesolid which precipitates is collected by filtration, washed with 10%sodium chloride solution, and dried at 60° C.

EXAMPLE 6 Preparation ofN-(2-(Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline

N-(2-Hydroxyethyl)-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline (110 g.)is treated exactly as in Example 5 to yield the sulfate product which isa white solid.

EXAMPLE 7 Preparation ofN-(2-(Sulfatoethyl)-2,3-dihydro-3,6-dimethyl-1,4-benzoxazine

N-(2-Hydroxyethyl)-2,3-dihydro-3,6-dimethyl-1,4-benzoxazine (25 g.) isadded at about 30° C. to concentrated sulfuric acid (50 ml). Aftersolution is complete, stirring is continued for 1 hr. and the reactionsolution drowned in ice-water to produce a total volume of about 500 ml.The coupler solution is used without further treatment.

The following are typical coupler types bearing hydroxy groups which maybe treated in a similar manner as described above to produce sulfategroups. ##STR6##

The tetrahydroquinoline and 2,3-dihydro-1,4-benzoxazine couplers can beprepared in a similar manner as illustrated by the aniline derivativesabove.

PREPARATION OF THE DYES--METHOD I EXAMPLES 8-17 Diazotization andCoupling of 2-Amino-6-methylbenzothiazole

To 150 g. of 60% acetic acid containing 10 g. of concentrated H₂ SO₄ isadded 8.2 g. (0.05 mole) of 2-amino-6-methylbenzothiazole at roomtemperature. The solution is cooled to -5° C., and a solution of 3.6 g.NaNO₂ in 20 ml of concentrated H₂ SO₄ is added below 0° C. The reactionmixture is stirred at -5° to 0° C. for 1.5 hours. Each of the couplers(0.005 mole) listed below as Examples 8-17 is added to water, or a 0.005mole aliquot of the coupler in dilute sulfuric acid is added to water,and cooled in an ice bath.

To each chilled coupler is added a 0.005 mole aliquot of the diazoniumsolution. The coupling mixture is treated with enough potassium acetateto neutralize the mineral acid. Water is added to the coupling mixtureto a total volume of about 200 ml and the dyes collected by filtration,washed with 10% KCl solution, and dried in air. The dyes usually areadmixed with about an equal weight of K₂ SO₄ and are used for dyeingwithout further purification to produce red shades on polyamides.

    ______________________________________                                        Example                                                                       No.                                                                           ______________________________________                                        8      N-Ethyl-N(-2-sulfatoethyl)aniline                                      9      N-Ethyl-N-(2-sulfatoethyl)-m-toluidine                                 10     N-(2-Sulfatoethyl)-o-chloroaniline                                     11     2-Methoxy-5-methyl-N-(2-sulfatoethyl)aniline                           12     N,N-bis(Sulfatoethyl)-m-toluidine                                      13     N-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4,7-                                tetramethylquinoline                                                   14     N-(2-Sulfatoethyl)-1,2,3,4-tetrahydro-2,2,4-                                  trimethylquinoline                                                     15     2,7-Dimethyl-N-(2-sulfatoethyl)-1,2,3,4-                                      tetrahydroquinoline                                                    16     2,3-Dihydro-3,6-dimethyl-N-(2-sulfatoethyl)-                                  1,4-benzoxazine                                                        17     2,3-Dihydro-3-methyl-6-methoxy-N-(2-sulfatoethyl)-                            1,4-benzoxazine                                                        ______________________________________                                    

EXAMPLES 18-27 Diazotization and Coupling of 3-Amino-2,1-benzisothiazole

To 25 ml of concentrated H₂ SO₄ is added 3.6 g. of NaNO₂ portionwisebelow 80° C. The solution is cooled and 50 ml of 1:5 acid (1 partpropionic, 5 parts acetic acid) is added below 20° C. The mixture isfurther cooled and 3-amino-2,1-benzisothiazole (7.5 g., 0.05 m) isadded, followed by 50 ml of 1:5 acid, all at 0°-5° C. The diazonium,after stirring at 0°-5° C. for 1 hr., is coupled to the couplers ofExamples 8-17 in a similar manner as above to produce violet to reddishblue dyes for polyamides.

EXAMPLES 28-37 Diazotization and Coupling of2-Amino-5-ethylthio-1,3,4-thiadiazole

Sodium nitrite (3.6 g.) is added portionwise to 25 ml of concentrated H₂SO₄. The solution is cooled and 100 ml of 1:5 acid is added below 15° C.The mixture is cooled and 8.05 g. (0.05 m) of2-amino-5-ethylthio-1,3,4-thiadiazole is added below 10° C. Afterstirring at 0°-5° C. for 2 hrs., a 0.005 m aliquot of the diazonium saltis coupled to 0.005 m of the couplers of Examples 8-17 to produce reddyes for polyamides.

EXAMPLES 38-47 Diazotization of 5-Amino-3-ethylthio-1,2,4-thiadiazole

5-Amino-3-ethylthio-1,2,4-thiadiazole (8.05 g., 0.05 m) is diazotizedexactly as described in Examples 28-37 and a 0.005 m aliquot coupled to0.005 m portion of the couplers of Examples 8-17 in the mannerpreviously illustrated.

EXAMPLES 48-57 Diazotization of 5-Amino-3-methyl-4-cyano isothiazole

To 25 ml of concentrated H₂ SO₄ is added 3.6 g. of NaNO₂ allowing thetemperature to rise. The solution is cooled and 50 ml of 1:5 acid isadded below 10° C. Stirring is continued and 6.95 g. (0.05 m) of5-amino-3-methyl-4-cyanoisothiazole is added below 5° C., followed by anadditional 50 ml of 1:5 acid. After stirring at 0°-5° C. for 2 hrs., a0.005 m aliquot of the diazonium salt is coupled to 0.005 m of thecouplers of Examples 8-17 as previously described to produce rubine toviolet dyes for polyamides.

EXAMPLES 58-67 Diazotization of 5-Amino-4-carbomethoxypyrazole

Nitrosyl sulfuric acid is prepared by adding 3.6 g. NaNO₂ to 25 ml ofconcentrated H₂ SO₄. The solution is cooled and 100 ml of 1:5 acid isadded below 20° C. After further cooling, 5-amino-4-carbomethoxypyrazole(7.05 g., 0.05 m) is added at 0°-5° C. and stirring continued for 2 hrs.A 0.005 m aliquot of the diazonium solution is coupled to 0.005 m. ofthe couplers of Examples 8-17 in the manner previously described toproduce red dyes for polyamides.

EXAMPLES 68-77 Diazotization of2-Amino-3-carbomethoxy-5-isobutyrylthiophene

To 150 g. of 60% aqueous acetic acid is added 11.35 g. (0.05 m) of2-amino-3-carbomethoxy-5-isobutylthiophene at room temperature. Tengrams of concentrated onc. H₂ SO₄ is added and the mixture cooled to 0°C. A solution of 3.6 g NaNO₂ in 25 ml of conc. H₂ SO₄ is added below 10°C. and stirring continued for 1 hr. at 0°-5° C. A 0.005 m aliquot ofthis diazonium salt is coupled to 0.005 m portions of the couplers ofExamples 8-17 as previously illustrated to produce violet toreddish-blue dyes for polyamides.

PREPARATION OF DYES--METHOD II EXAMPLE 78 Reaction of Hydroxy ContainingDye With Sulfuric Acid and NaOH ##STR7##

To 50 g. of concentrated H₂ SO₄ is added 10 g. of Dye I portionwise,allowing the temperature to rise (40° C.). The temperature is thenincreased to about 50°-55° C. for about 30 min. After cooling to roomtemperature, the reaction mixture is added to 50 g. of ice and 20 ml ofacetic acid. A solution of 105 g. of 50% NaOH is added, with ice forinternal cooling, below 30° C. The slurry was diluted with 200 ml ofwater and then filtered. The solid is dried at room temperature andcontains about an equal weight of dye and sodium sulfate. The dyeproduces bright bluish-red shades on nylon carpet.

EXAMPLE 79 ##STR8##

Dye II (1 g.) is added to 3 g. of concentrated H₂ SO₄ and the mixturewarmed at 45°-50° C. to complete solution. After 15 min. 10 g. of ice isadded and 50% potassium hydroxide solution is added until pH of about 8is obtained. Water (75 ml) is added and the dye collected by filtrationand dried in air. The dye produces bright blue shades on polyamidefibers.

                                      TABLE I                                     __________________________________________________________________________     ##STR9##                                                                     Substituents on                                                               Ring A     (R.sub.1)m R.sub.2       Z                M                        __________________________________________________________________________    None       None       C.sub.2 H.sub.5                                                                             CH.sub.2 CH.sub.2                                                                              K.sup.+                  "          "          C.sub.6 H.sub.11                                                                            "                "                        "          "          C.sub.6 H.sub.5                                                                             "                "                        "          3CH.sub.3  C.sub.2 H.sub.5                                                                             "                "                        "          "          CH.sub.2 C.sub.6 H.sub. 5                                                                   "                "                        "          "          CH.sub.2 CH.sub.2 OCH.sub.3                                                                 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                            "                        "          "          CH.sub.2 CH.sub.2 CONH.sub.2                                                                CH.sub.2 CH.sub.2                                                                              "                        "          "          CH.sub.2 CH.sub.2 Cl                                                                        "                "                        "          3-NHCOCH.sub.3                                                                           C.sub.2 H.sub.5                                                                             "                "                        "          2-CH.sub.3 -5-NHCOCH.sub.3                                                               H             "                "                        "          2-OCH.sub.3 -5-CH.sub.3                                                                  "             "                "                        "          2-Cl       "             "                "                        "          2-CH.sub.3 "             "                "                        "          2,5-di-Cl  "             "                "                        "          2-OCH.sub.3 -5-Cl                                                                        "             "                "                        6-CH.sub.3 2-OCH.sub.3 -5-CH.sub.3                                                                  "             "                "                        "          2,5-diCH.sub.3                                                                           "             "                Na.sup.+                 "          3-CH.sub.3                                                                                ##STR10##    "                "                        "          3-CH.sub.3                                                                                ##STR11##     CH.sub.2 CH(CH.sub.2 Cl)                                                                      "                        "          3-CH.sub.3                                                                                ##STR12##    CH.sub.2 CH.sub.2                                                                              NH.sub.4.sup.+           "          3-CH.sub.3                                                                                ##STR13##    "                K.sup.+                  "3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                    "             "                                         "          3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                     "                "                        6-OCH.sub.3                                                                              None       CH.sub.3      CH.sub.2 CH.sub.2                                                                              "                        "          3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                           "                        "          "          CH.sub.2 C.sub.6 H.sub.11                                                                   CH.sub.2 CH.sub.2                                                                              "                        "          "          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                          "                "                        6-C1       "          CH(CH.sub.3).sub.2                                                                          "                "                        "          H          CH.sub.2 CH.sub.3                                                                           "                K.sup.+                  "          "          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                 H.sub.5       "                "                        5,6-di-Cl  3-CH.sub.3 CH.sub.2 CH.sub.3                                                                           "                "                        6-SO.sub.2 CH.sub.3                                                                      "          "             "                "                        6-CN       "          "             "                "                        6-CONH.sub.2                                                                             "          "             "                "                        6-COCH.sub.3                                                                             3-NHCOC.sub.6 H.sub.5                                                                    "             "                "                        6-COC.sub.6 H.sub.5                                                                      3-NHCONHC.sub.2 H.sub.5                                                                  "             "                "                        6-COOC.sub.2 H.sub.5                                                                     3-NHCOCH.sub.2 OCH.sub.3                                                                 "             "                "                        6-SO.sub.2 NH.sub.2                                                                      3-NHCOC.sub.6 H.sub.11                                                                   "             "                "                        6-SO.sub.2 N(CH.sub.3).sub.2                                                             3-NHCOOC.sub.2 H.sub.5                                                                   "             CH.sub.2 CH(CH.sub.3)                                                                          "                        6-SO.sub.2 NHC.sub.2 H.sub.4 OCH.sub.3                                                   3-NHCOCH.sub.2 CN                                                                        "             CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                "                        6-NHCOCH.sub.3                                                                           "          "             CH.sub.2 CH.sub.2                                                                              "                        4-CF.sub.3 None       "             "                "                        6-SO.sub.3 C.sub.6 H.sub.5                                                               "          "             "                "                        6-OC.sub.2 H.sub.5                                                                       3-CH.sub.3 "             CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                           "                        "          "          "             CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2 CH.sub.2 CH.sub.2                                                                     "                        "          "          "             CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)                                        CH.sub.2 CH.sub.2                                                                              "                        "          "          "             CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.                                        2 CH.sub.2       "                        "          "          "             CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2         "                        6-SCH.sub.3                                                                              "          "             CH.sub.2 CH.sub.2                                                                              "                        6-SCN      "          "             "                "                        6-CH.sub.3 "          "             CH.sub.2 CH.sub.2 CONHC.sub.2                                                                  ".sub.4                  "          "          "             CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                 "                        "          "          "             CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2                                         CH.sub.2         "                        "          3-NHCOC.sub.6 H.sub.5                                                                    "             CH.sub.2 CH.sub.2                                                                              "                        "          3-NHCOOC.sub.2 H.sub.5                                                                   "             "                "                        "          3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                              "                Na.sup.+                 "          "          C.sub.2 H.sub.5                                                                             CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                              "                        __________________________________________________________________________

                                      TABLE 2                                     __________________________________________________________________________     ##STR14##                                                                    Substituents on                                                               Ring A    (R.sub.1)m                                                                              R.sub.3                                                                          Z     M                                                __________________________________________________________________________    None      None      CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.2  K.sup.+                       "         "         H  CH.sub.3                                                                            "                  "                             "         "         H  CH.sub.3                                                                            "                  "                             "         7-CH.sub.3                                                                              "  "     "                                                "         "         CH.sub. 3                                                                        "     "                  "                             "         7-CH.sub.3                                                                              H  CH(CH.sub.3).sub.2                                                                  "                  "                             "         7-OCH.sub.3                                                                             "  CH.sub.3                                                                            "                  "                             "         5-OCH.sub.3, 8-CH.sub.3                                                                 "  "     "                  "                             "         5,8-di-OCH.sub.3                                                                        "  "     "                  "                             "         5,8-di-CH.sub.3                                                                         "  "     "                  "                             "         7-Cl      "  "     "                  "                             "         5,8-di-Cl "  "     "                  "                             6-CH.sub.3                                                                              None      "  "     "                  Na.sup.+                      "         5-OCH.sub.3, 8-CH.sub.3                                                                 CH.sub.3                                                                         "     "                  "                             "         7-NHCHO   "  "     "                  "                             "         7-NHCOCH.sub.3                                                                          "  "     "                  "                             "         7-NHCOCH.sub.2 OCH.sub.3                                                                "  "     "                  "                             "         7-NHCOOC.sub.2 H.sub.5                                                                  "  "     "                  "                             "         7-NHCOC.sub.6 H.sub.5                                                                   "  "     "                  "                             "         7-NHCONHC.sub.2 H.sub.5                                                                 "  "     "                  K.sup.+                       "         7-NHCOC.sub.6 H.sub.11                                                                  "  "     "                  "                             6-OCH.sub.3                                                                             None      "  "     "                  "                             "         7-CH.sub.3                                                                              H  "     "                  "                             "         "         "  H     "                  "                             6-OCH.sub.2 CH.sub.3                                                                    "         "  CH.sub.3                                                                            "                  "                             6-SCH.sub.3                                                                             "         "  "     "                  "                             6-SCN     "         "  "     "                  "                             6-SO.sub.2 NH.sub.2                                                                     "         "  "     "                  "                             6-SO.sub.2 NHC.sub.4 H.sub.9 -n                                                         "         "  "     "                  "                             6-SO.sub.2 N(CH.sub.3).sub.2                                                            7-OCH.sub.3                                                                             "  "     "                  "                             6-SO.sub.3 C.sub.6 H.sub.5                                                              7-CH.sub.3                                                                              "  "     "                  "                             6-CN      "         "  "     "                  "                             6-CONH.sub.2                                                                            "         "  "     "                  "                             4-COOCH.sub.3                                                                           "         "  "     "                  "                             6-COCH.sub.3                                                                            "         "  "     "                  "                             6-COC.sub.6 H.sub.5                                                                     "         "  "     "                  "                             6-Cl      None      "  "     "                  "                             5,6-di-Cl "         "  "     "                  "                             4-Br      "         "  "     "                  "                             4-CF.sub.3                                                                              "         "  "     "                  "                             6-NHCOCH.sub.3                                                                          7-CH.sub.3                                                                              "  "     "                  "                             6-SO.sub.2 CH.sub.3                                                                     "         "  "     "                  "                             6-CH.sub.3                                                                              "         "  "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                             "         "         "  "     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                             "         "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2                                                     "                             "         "         "  "     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.                                 2 CH.sub.2         "                             "         "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2           "                             "         "         "  "      CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                         "                             None      "         "  "     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.                                                           "                             6-SC.sub.2 H.sub.4 CN                                                                   "         "  "     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.sub.                                 2 CH.sub.2         "                             6-NHCOCH.sub.2 CN                                                                       "         "  "     CH.sub.2 CH.sub.2 (CH.sub.3)                                                                     "                             6-CH.sub.3                                                                              "         "  "     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+                      "         "         "  "     CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                             "         "         "  "     CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                             "         "         "  "     CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                             "         "         "  "     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                             "         "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.sub.                                 2 CH.sub.2 CH.sub.2                                                                              "                             6-COOC.sub. 2 H.sub.4 OCH.sub.3                                                         "         "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                             __________________________________________________________________________

                                      TABLE 3                                     __________________________________________________________________________     ##STR15##                                                                    Ring A      (R.sub.1)m                                                                              R.sub.3                                                                           Z                  M                                __________________________________________________________________________    None        None      H   CH.sub.2 CH.sub.2  Na.sup.+                         "           6-CH.sub.3                                                                              "   "                  "                                "           "         3-CH.sub.3                                                                        "                  "                                "           6-OCH.sub.3                                                                             "   "                  "                                6-CH.sub.3  "         H   "                  "                                "           6-CH.sub.3                                                                              3-CH.sub.3                                                                        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                              "                                4-CH.sub.3  "         "   CH.sub.2 CH.sub.2  "                                4-Cl        "         "   "                  "                                4-CF.sub.3  "         "   "                  "                                4,7-di-CH.sub.3                                                                           "         "   "                  "                                4,7-di-Cl   "         "   "                  "                                4-OCH.sub.3, 7-Cl                                                                         "         "   "                  "                                4-OCH.sub.3, 5-CH.sub.3                                                                   "         "   "                  "                                6-OCH.sub.3 "         "   "                  "                                "           6-NHCOCH.sub.3                                                                          "   "                  K.sup.+                          "           6-NHCOC.sub.6 H.sub.5                                                                   "   "                  "                                "           6-NHCOC.sub.4 H.sub.9n                                                                  "   "                  "                                "           6-NHCONHC.sub.2 H.sub.5                                                                 "   "                  "                                "           6-NHCOCH.sub.2 OCH.sub.3                                                                "   "                  "                                6-OC.sub.4 H.sub.9n                                                                       6-NHCOCH.sub.2 CN                                                                       "   "                  "                                6-SCH.sub.3 6-CH.sub.3                                                                              "   "                  Na.sup.+                         6-SCN       "         "   "                  "                                6-SO.sub.2 CH.sub.3                                                                       "         "   "                  "                                6-SO.sub.2 NH.sub.2                                                                       "         "   "                  "                                6-SO.sub.2 NHC.sub.2 H.sub.5                                                              "         "   "                  "                                6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                       "         "   "                  "                                6-SO.sub.2 NHC.sub.2 H.sub.4 OCH.sub.3                                                    "         "   "                  "                                6-SO.sub.3 C.sub.6 H.sub.5                                                                "         "   "                  "                                5,6-di-Cl   "         "   "                  "                                "           6-NHCHO   "   "                  "                                6-CN        6-CH.sub.3                                                                              "   "                  "                                6-CONH.sub.2                                                                              "         "   "                  "                                6-COOC.sub.2 H.sub.5                                                                      "         "   "                  "                                6-COCH.sub.3                                                                              "         "   "                  "                                6-COC.sub.6 H.sub.5                                                                       "         "   "                  "                                4-Br6-SO.sub.2 CH.sub.3                                                                   "         "   "                  "                                6-SCH.sub.2 CH.sub.2 CN                                                                   "         "   "                  "                                6-SO.sub.2 CH.sub.2 CH.sub.2 CN                                                           "         "   "                  "                                6-CH.sub.3  "         "   CH.sub.2 CH(CH.sub.3)                                                                            "                                "           "         "   CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                                "           "         "   CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                                "           "         "   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                                "           "         "   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                                "           "         "   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                                "           "         "   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                                "           "         "   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2                                                     "                                "           "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3 )CH.sub.2                               CH.sub.2           "                                "           "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)CH.                              sub.2 CH.sub.2     "                                "           "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2                                CH.sub.2           "                                "           "         "   CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                                "           "         "   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2                                CH.sub.2           "                                "           "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                                "           "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                       CH.sub.2 CH.sub.2  "                                "           "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)CH.                              sub.2 CH.sub.2     "                                "           "         "   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2                                                        "                                6-COOCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                   "         "   CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                                "           "         "   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2                                  CH.sub.2           "                                __________________________________________________________________________

                                      TABLE 4                                     __________________________________________________________________________     ##STR16##                                                                    Substitution                                                                  Ring B     (R.sub.1)m R.sub.2       Z                M                        __________________________________________________________________________    6-CH.sub.3 None       C.sub.2 H.sub.5                                                                             CH.sub.2 CH.sub.2                                                                              K.sup.+                  None       "          C.sub.6 H.sub.11                                                                            "                "                        "          "          C.sub.6 H.sub.5                                                                             "                "                        6-CH.sub.3 3CH.sub.3  C.sub.2 H.sub.5                                                                             "                "                        None       "          CH.sub.2 C.sub.6 H.sub.5                                                                    "                "                        "          "          CH.sub.2 CH.sub.2 OCH.sub.3                                                                 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                            "                        "          "          CH.sub.2 CH.sub.2 CONH.sub.2                                                                CH.sub.2 CH.sub.2                                                                              "                        "          "          CH.sub.2 CH.sub.2 Cl                                                                        "                "                        "          3-NHCOCH.sub.3                                                                           C.sub.2 H.sub.5                                                                             "                "                        "          2-CH.sub.35-NHCOCH.sub.3                                                                 H             "                "                        6-OCH.sub.3                                                                              2-OCH.sub.35-CH.sub.3                                                                    "             "                "                        "          2-Cl       "             "                "                        None       2-CH.sub.3 "             "                "                        "          2,5-di-Cl  "             "                "                        "          2-OCH.sub.35-Cl                                                                          "             "                "                        6-CH.sub.3 2-OCH.sub.35-CH.sub.3                                                                    "             "                "                        None       2,5-di-CH.sub.3                                                                          "             "                "                        "          3-CH.sub.3                                                                                ##STR17##    "                "                        "          3-CH.sub.3                                                                                ##STR18##    CH.sub.2 CH(CH.sub.2 Cl)                                                                       "                        "          3-CH.sub.3                                                                                ##STR19##    CH.sub.2 CH.sub.2                                                                              NH.sub.4.sup.+           "          3-CH.sub.3                                                                                ##STR20##    "                K.sup.+                  "          3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                       "                "                        "          3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                     "                "                        5-Cl       None       CH.sub.3      CH.sub.2 CH.sub.2                                                                              "                        5-Br       3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                 CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                           "                        6-SO.sub.2 NH.sub.2                                                                      "          CH.sub.2 C.sub.6 H.sub.11                                                                   CH.sub.2 CH.sub.2                                                                              "                        6-SO.sub.2 NHC.sub.2 H.sub.5                                                             "          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                          "                "                        6-SO.sub.2 N(CH.sub.3).sub.2                                                             "          CH(CH.sub.3).sub.2                                                                          "                "                        6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                                   H          CH.sub.2 CH.sub.3                                                                           "                K.sup.+                  5-Cl       "          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                 H.sub.5       "                "                        "          3-CH.sub.3 CH.sub.2 CH.sub.3                                                                           "                "                        "          "          "             "                "                        "          "          "             "                "                        "          "          "             "                "                        None       3-NHCOC.sub.6 H.sub.5                                                                    "             "                "                        "          3-NHCONHC.sub.2 H.sub.5                                                                  "             "                "                        "          3-NHCOCH.sub.2 OCH.sub.3                                                                 "             "                "                        "          3-NHCOC.sub.6 H.sub.11                                                                   "             "                "                        "          3-NHCOOC.sub.2 H.sub.5                                                                   "             CH.sub.2 CH(CH.sub.3)                                                                          "                        "          3-NHCOCH.sub.2 CN                                                                        "             CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                "                        6-SO.sub.2 NHCH.sub.3                                                                    "          "             CH.sub.2 CH.sub.2                                                                              "                        "          None       "             "                "                        "          "          "             "                "                        None       3-CH.sub.3 "             CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                           "                        "          "          "             CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2 CH.sub.2 CH.sub.2                                                                     "                        "          "          "             CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)                                        CH.sub.2 CH.sub.2                                                                              "                        "          "          "             CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.                                        2 CH.sub.2       "                        "          "          "             CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2         "                        "          "          "             CH.sub.2 CH.sub.2                                                                              "                        "          "          "             "                "                        "          "          "             CH.sub.2 CH.sub.2 CONHC.sub.2                                                                  ".sub.4                  "          "          "             CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                 "                        "          "          "             CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2                                         CH.sub.2         "                        "          3-NHCOC.sub.6 H.sub.5                                                                    "             CH.sub.2 CH.sub.2                                                                              "                        "          3-NHCOOC.sub.2 H.sub.5                                                                   "             "                "                        6-CH.sub.3 3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                              "                Na.sup.+                 None       "          C.sub.2 H.sub.5                                                                             CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                              "                        __________________________________________________________________________

                                      TABLE 5                                     __________________________________________________________________________     ##STR21##                                                                    Substituents on                                                               Ring B   (R.sub.1).sub.m                                                                        R.sub.3                                                                          R.sub.4                                                                            Z                  M                                __________________________________________________________________________    6-CH.sub.3 None      CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.2  K.sup.+                      "          "         H  CH.sub.3                                                                            "                  "                            "          7-CH.sub.3                                                                              "  "     "                  "                            "          "         CH.sub.3                                                                         "     "                  "                            "          7-CH.sub.3                                                                              H  CH(CH.sub.3).sub.2                                                                  "                  "                            None       7-OCH.sub.3                                                                             "  CH.sub.3                                                                            "                  "                            "          5-OCH.sub.3, 8-CH.sub.3                                                                 "  "     "                  "                            "          5,8-di-OCH.sub.3                                                                        "  "     "                  "                            "          5,8-di-CH.sub.3                                                                         "  "     "                  "                            "          7-Cl      "  "     "                  "                            "          5,8-di-Cl "  "     "                  "                            "          None      "  "     "                  Na.sup.+                     "          5-OCH.sub.3, 8-CH.sub.3                                                                 CH.sub.3                                                                         "     "                  "                            "          7-NHCHO   "  "     "                  "                            "          7-NHCOCH.sub.3                                                                          "  "     "                  "                            "          7-NHCOCH.sub.2 OCH.sub.3                                                                "  "     "                  "                            "          7-NHCOOC.sub.2 H.sub.5                                                                  "  "     "                  "                            "          7-NHCOC.sub.6 H.sub.5                                                                   "  "     "                  "                            "          7-NHCONHC.sub.2 H.sub.5                                                                 "  "     "                  K.sup.+                      "          7-NHCOC.sub.6 H.sub.11                                                                  "  "     "                  "                            5-Cl       None      "  "     "                  "                            "          7-CH.sub.3                                                                              H  "     "                  "                            "          "         "  H     "                  "                            "          "         "  CH.sub.3                                                                            "                  "                            5-Br       "         "  "     "                  "                            6-SO.sub.2 NH.sub.2                                                                      "         "  "     "                  "                            6-SO.sub.2 NHC.sub.2 H.sub.5                                                             "         "  "     "                  "                            6-SO.sub.2 N(CH.sub.3).sub.2                                                             "         "  "     "                  "                            6-SO.sub.2 N(CH.sub.3 C.sub.2 H.sub.4 OH                                                 7-OCH.sub.3                                                                             "  "     "                  "                            6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                                   7-CH.sub.3                                                                              "  "     "                  "                            6-OCH.sub.3                                                                              "         "  "     "                  "                            "          "         "  "     "                  "                            "          "         "  "     "                  "                            5-Cl       "         "  "     "                  "                            "          "         "  "     "                  "                            "          None      "  "     "                  "                            "          "         "  "     "                  "                            "          "         "  "     "                  "                            "          "         "  "     "                  "                            "          7-CH.sub.3                                                                              "  "     "                  "                            "          "         "  "     "                  "                            None       "         "  "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                            "          "         "  "     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                            "          "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                                              "H.sub.2                     "          "         "  "     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub                                  .2 CH.sub.2        "                            "          "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2           "                            "          "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                          "                            "          "         "  "     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                            "          "         "  "     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.sub                                  .2 CH.sub.2        "                            "          "         "  "     CH.sub.2 CH.sub.2 (CH.sub.3)                                                                     "                            "          "         "  "     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+                     "          "         "  "     CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                            "          "         "  "     CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                            "          "         "  "     CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                            "          "         "  "     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                            "          "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.sub                                  .2 CH.sub.2 CH.sub.2                                                                             "                            "          "         "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                            __________________________________________________________________________

                                      TABLE 6                                     __________________________________________________________________________     ##STR22##                                                                    Substituents on                                                               Ring B     (R.sub.1).sub.m                                                                         R.sub.3                                                                           Z                 M                                  __________________________________________________________________________    None       None      H   CH.sub.2 CH.sub.2 Na.sup.+                           "          6-CH.sub.3                                                                              "   "                 "                                  6-CH.sub.3 "         3-CH.sub.3                                                                        "                 "                                  "          6-OCH.sub.3                                                                             "   "                 "                                  None       "         H   "                 "                                  "          6-CH.sub.3                                                                              3-CH.sub.3                                                                        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                             "                                  "          "         "   CH.sub.2 CH.sub.2 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          6-NHCOCH.sub.3                                                                          "   "                 K.sup.+                            "          6-NHCOC.sub.6 H.sub.5                                                                   "   "                 "                                  "          6-NHCOC.sub.4 H.sub.9 -n                                                                "   "                 "                                  "          6-NHCONHC.sub.2 H.sub.5                                                                 "   "                 "                                  5-Br       6-NHCOCH.sub.2 OCH.sub.3                                                                "   "                 "                                  6-OCH.sub.3                                                                              6-NHCOCH.sub.2 CN                                                                       "   "                 "                                  6-SO.sub.2 NH.sub.2                                                                      6-CH.sub.3                                                                              "   "                 Na.sup.+                           6-SO.sub.2 NHC.sub.4 H.sub.9 -n                                                          "         "   "                 "                                  6-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                                   "         "   "                 "                                  6-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                      "         "   "                 "                                  6-SO.sub.2 N(C.sub.2 H.sub. 4 OH).sub.2                                                  "         "   "                 "                                  6-SO.sub.2 NHC.sub.6 H.sub.11                                                            "         "   "                 "                                  6-SO.sub.2 N(CH.sub.3)C.sub.2 H.sub.4 OH                                                 "         "   "                 "                                  5-Cl       "         "   "                 "                                  "          "         "   "                 "                                  "          6-NHCHO   "   "                 "                                  "          6-CH.sub.3                                                                              "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   "                 "                                  None       "         "   "                 "                                  "          "         "   "                 "                                  "          "         "   CH.sub.2 CH(CH.sub.3)                                                                           "                                  "          "         "   CH.sub.2 CH(C.sub.6 H.sub.5)                                                                    "                                  "          "         "   CH.sub.2 CH(CH.sub.2 Cl)                                                                        "                                  "          "         "   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                "                                  "          "         "   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                          "                                  "          "         "   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                            "                                  "          "         "   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                            "                                  "          "         "   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2                                                    "                                  "          "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.2                                CH.sub.2          "                                  "          "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)CH.s                             ub.2 CH.sub.2     "                                  "          "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2                                CH.sub.2          "                                  "          "         "   CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                  "                                  "          "         "   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2                                CH.sub.2          "                                  "          "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                         "                                  "          "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2 CH.sub.2                              CH.sub.2          "                                  "          "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)CH.s                             ub.2 CH.sub.2     "                                  "          "         "   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2                                                       "                                  "          "         "   CH.sub.2 CH.sub.2 CH.sub.2                                                                      "                                  "          "         "   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2                                  CH.sub.2          "                                  __________________________________________________________________________

                                      TABLE 7                                     __________________________________________________________________________     ##STR23##                                                                    Substituents on                                                               Ring C       (R.sub.1).sub.m                                                                          R.sub.2      Z                M                       __________________________________________________________________________    5-CH.sub.3   None       C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2                                                                              K.sup.+                 5-CH.sub.2 CH.sub.3                                                                        "          C.sub.6 H.sub.11                                                                           "                "                       5-CH.sub.2 CH(CH.sub.3)                                                                    "          C.sub.6 H.sub.5                                                                            "                "                       5-C.sub.6 H.sub.5                                                                          3-CH.sub.3 C.sub.2 H.sub.5                                                                            "                "                       5-C.sub.6 H.sub.11                                                                         "          CH.sub.2 C.sub.6 H.sub.5                                                                   "                "                       5-C.sub.6 H.sub.4 -p-Cl                                                                    "          CH.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                            "                       5-C.sub.6 H.sub.4OCH.sub.3                                                                 "          CH.sub.2 CH.sub.2 CONH.sub.2                                                               CH.sub.2 CH.sub.2                                                                              "                       5-C.sub.6 H.sub.4 -m-OCH.sub. 3                                                            "          CH.sub.2 CH.sub.2 Cl                                                                       "                "                       5-SCH.sub.3  3-NHCOCH.sub.3                                                                           C.sub.2 H.sub.5                                                                            "                "                       "            2-CH.sub.3 -5-NHCOCH.sub.3                                                               H            "                "                       "            2-OCH.sub.3 -5-CH.sub.3                                                                  "            "                "                       "            2-Cl       "            "                "                       "            2-CH.sub.3 "            "                "                       "            2,5-di-Cl  "            "                "                       "            2-OCH.sub.3 -5-Cl                                                                        "            "                "                       "            2-OCH.sub.3 -5-CH.sub.3                                                                  "            "                "                       5-OC.sub.2 H.sub.5                                                                         2,5-di-CH.sub.3                                                                          "            "                Na.sup.+                5-SC.sub.2 H.sub.5                                                                         3-CH.sub.3                                                                                ##STR24##   "                "                       "            3-CH.sub.3                                                                                ##STR25##   CH.sub.2 CH(CH.sub.2 Cl)                                                                       "                       "            3-CH.sub.3                                                                                ##STR26##   CH.sub.2 CH.sub.2                                                                              NH.sub.4.sup.+          "            3-CH.sub.3                                                                                ##STR27##   "                K.sup.+                 "            3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                      "                "                       "            3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                    "                "                       "            None       CH.sub.3     CH.sub.2 CH.sub.2                                                                              "                       5-Cl         3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                           "                       5-SO.sub.2 CH.sub.3                                                                        "          CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.2 CH.sub.2                                                                              "                       5-OC.sub.4 H.sub.9 -n                                                                      "          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                         "                "                       5-SCH.sub.2 CH.sub.2 OH                                                                    "          CH(CH.sub.3).sub.2                                                                         "                "                       5-SCH.sub.2 CH.sub.2 COOCH.sub.3                                                           H          CH.sub.2 CH.sub.3                                                                          "                K.sup.+                  ##STR28##   "          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                 H.sub.5      "                "                       5-SCH.sub.2 SC.sub.6 H.sub.5                                                               3-CH.sub.3 CH.sub.2 CH.sub.3                                                                          "                "                       5-SO.sub.2 CH.sub.3                                                                        "          "            "                "                       5-SO.sub.2 NH.sub.2                                                                        "          "            "                "                       5-SO.sub.2 NHC.sub.2 H.sub.5                                                               "          "            "                "                       5-SCN        3-NHCOC.sub.6 H.sub.5                                                                    "            "                "                       5-SO.sub.2 N(CH.sub.3).sub.2                                                               3-NHCONC.sub.2 H.sub.5                                                                   "            "                "                       5-SO.sub.3 (C.sub.6 H.sub.5)                                                               3-NHCOCH.sub.2 OCH.sub.3                                                                 "            "                "                       5-SCH.sub.3 CHCH.sub.2                                                                     3-NHCOC.sub.6 H.sub.11                                                                   "            "                "                       5-SCH.sub.2 CH.sub.2 OCH.sub.3                                                             3-NHCOOC.sub.2 H.sub.5                                                                   "            CH.sub.2 CH(CH.sub.3)                                                                          "                        ##STR29##   3-NHCOCH.sub.2 CN                                                                        "            CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                "                       5-SC.sub.6 H.sub.11                                                                        "          "            CH.sub.2 CH.sub.2                                                                              "                       5-SC.sub.6 H.sub.5                                                                         None       "            "                "                       5-SO.sub.2 C.sub.6 H.sub.5                                                                 "          "            "                                        5-I          3-CH.sub.3 "            CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                           "                       5-Br         "          "            CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2 CH.sub.2 CH.sub.2                                                                     "                        ##STR30##   "          "            CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                     "                       5-SCH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                   "          "            CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub                                         .2 CH.sub.2      "                       5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                                          "          "            CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                          CH.sub.2        "                       5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      "          "            CH.sub.2 CH.sub.2                                                                              "                       5-SCH.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                       "          "            "                "                       5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      "          "            CH.sub.2 CH.sub.2 CONHC.sub.2                                                                  ".sub.4                 5-SO.sub.2 C.sub.6 H.sub.11                                                                "          "            CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                 "                       5-CH.sub.3   "          "            CH.sub.2 CH.sub.2 NHSO.sub.2                                                  CH.sub.2 CH.sub.2                                                                              "                       "            3-NHCOC.sub.6 H.sub.5                                                                    "            CH.sub.2 CH.sub.2                                                                              "                       "            3-NHCOOC.sub.2 H.sub.5                                                                   "            "                "                       5-NHCOCH.sub.3                                                                             3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                             "                Na.sup.+                "            "          C.sub.2 H.sub.5                                                                            CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                              "                       __________________________________________________________________________

                                      TABLE 8                                     __________________________________________________________________________     ##STR31##                                                                    Substituents on                                                               Ring C       (R.sub.1).sub.m                                                                         R.sub.3                                                                          R.sub.4                                                                             Z                  M                          __________________________________________________________________________    None         None      CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.2  K.sup.+                    "            "         H  CH.sub.3                                                                            "                  "                          "            7-CH.sub.3                                                                              "  "     "                  "                          5-CH.sub.3   "         CH.sub.3                                                                         "     "                  "                          5-CH.sub.2 CH.sub.3                                                                        7-CH.sub.3                                                                              H  CH(CH.sub.3).sub.2                                                                  "                  "                          5-CH(CH.sub.3).sub.2                                                                       7-OCH.sub.3                                                                             "  CH.sub.3                                                                            "                  "                          5-CH.sub. 2 CH(CH.sub.3).sub.2                                                             5-OCH.sub.3, 8-CH.sub.3                                                                 "  "     "                  "                          5-C.sub.6 H.sub.5                                                                          5,8-di-OCH.sub.3                                                                        "  "     "                  "                          5-C.sub.6 H.sub.11                                                                         5,8-di-CH.sub.3                                                                         "  "     "                  "                          5-C.sub.6 H.sub.4 -o-Cl                                                                    7-Cl      "  "     "                  "                          5-C.sub.6 H.sub.4 -m-CH.sub. 3                                                             5,8-di-Cl "  "     "                  "                          5-C.sub.6 H.sub.4 -p-OCH.sub. 3                                                            None      "  "     "                  Na.sup.+                   5-OC.sub.2 H.sub.5                                                                         5-OCH.sub.3, 8-CH.sub.3                                                                 CH.sub.3                                                                         "     "                  "                          "            7-NHCHO   "  "     "                  "                          "            7-NHCOCH.sub.3                                                                          "  "     "                  "                          "            7-NHCOCH.sub.2 OCH.sub.3                                                                "  "     "                  "                          "            7-NHCOOC.sub.2 H.sub.5                                                                  "  "     "                  "                          "            7-NHCOC.sub.6 H.sub.5                                                                   "  "     "                  "                          "            7-NHCONHC.sub.2 H.sub.5                                                                 "  "     "                  K.sup.+                    5-Cl         7-NHCOC.sub.6 H.sub.11                                                                  "  "     "                  "                          "            None      "  "     "                  "                          "            7-CH.sub.3                                                                              H  "     "                  "                          "            "         "  H     "                  "                          5-I          "         "  CH.sub.3                                                                            "                  "                          5-Br         "         "  "     "                  "                          5-SO.sub.2 CH.sub.3                                                                        "         "  "     "                  "                          5-SO.sub.2 NH.sub.2                                                                        "         "  "     "                  "                          5-SO.sub.2 N(CH.sub.3).sub.2                                                               "         "  "     "                  "                          5-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                        7-OCH.sub.3                                                                             "  "     "                  "                          5-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                                     7-CH.sub.3                                                                              "  "     "                  "                          5-SO.sub.2 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                              "         "  "     "                  "                          5-SC.sub.6 H.sub.5                                                                         "         "  "     "                  "                          5-SC.sub.6 H.sub.11                                                                        "         "  "     "                  "                          5-SO.sub.2 C.sub.6 H.sub.5                                                                 "         "  "     "                  "                          5-SO.sub. 3 C.sub.6 H.sub.5                                                                "         "  "     "                  "                          5-SCH.sub.2 CH.sub.2 OH                                                                    None      "  "     "                  "                          5-SCH.sub.2 CHCH.sub.2                                                                     "         "  "     "                  "                          5-SCH.sub.2 COOC.sub.2 H.sub.5                                                             "         "  "     "                  "                          5-SCH.sub.2 C.sub.6 H.sub.5                                                                "         "  "     "                  "                          5-SCH.sub.2 C.sub.6 H.sub.11                                                               7-CH.sub.3                                                                              "  "     "                  "                          5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                      "         "  "     "                  "                          5-SCN        "         "  "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                          5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                                          "         "  "     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                           ##STR32##   "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2           "                          5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                      "         "  "     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.s                                    ub.2 CH.sub.2      "                          5-SCH.sub.2 CH.sub.3                                                                       "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2           "                          "            "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                          "                          "            "         "  "     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                          "            "         "  "     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.s                                    ub.2 CH.sub.2      "                          "            "         "  "     CH.sub.2 CH.sub.2 (CH.sub.3)                                                                     "                          "            "         "  "     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+                   "            "         "  "     CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                          5-SCH.sub.3  "         "  "     CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                          "            "         "  "     CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                          "            "         "  "     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                          "            "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.s                                    ub.2 CH.sub.2 CH.sub.2                                                                           "                          5-NHCOCH.sub.3                                                                             "         "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                          __________________________________________________________________________

                                      TABLE 9                                     __________________________________________________________________________     ##STR33##                                                                    Substituents on                                                               Ring C        (R.sub.1)m R.sub.3                                                                            Z                  M                            __________________________________________________________________________    None          None       H    CH.sub.2 CH.sub.2  Na.sup.+                     "             6-CH.sub.3 "    "                  "                            "             "          3-CH.sub.3                                                                         "                  "                            5-CH.sub. 3   6-OCH.sub.3                                                                              "    "                  "                            5-CH(CH.sub.3).sub.2                                                                        "          H    "                  "                            5-CH.sub.2 CH(CH.sub.3).sub.2                                                               6-CH.sub.3 3-CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                              "                            5-C.sub.6 H.sub.5                                                                           "          "    CH.sub.2 CH.sub.2  "                            5-C.sub.6 H.sub.4 -p-Cl                                                                     "          "    "                  "                            5-C.sub.6 H.sub.4 -p-OCH.sub. 3                                                             "          "    "                  "                            5-C.sub.6 H.sub.4 -m-CH.sub. 3                                                              "          "    "                  "                            5-OC.sub.2 H.sub.5                                                                          "          "    "                  "                            5-OCH(CH.sub.3).sub.2                                                                       "          "    "                  "                            5-C.sub.6 H.sub.11                                                                          "          "    "                  "                            5-SCN         "          "    "                  "                            5-SCH.sub.3   6-NHCOCH.sub.3                                                                           "    "                  K.sup.+                      5-SCH.sub.2 CH(CH.sub.3).sub.2                                                              6-NHCOC.sub.6 H.sub.5                                                                    "    "                  "                            5-SCH.sub.2 CHCH.sub.2                                                                      6-NHCOC.sub.4 H.sub.9 -n                                                                 "    "                  "                            5-SC.sub.6 H.sub.11                                                                         6-NHCONHC.sub.2 H.sub.5                                                                  "    "                  "                            5-SC.sub.6 H.sub.5                                                                          6-NHCOCH.sub.2 OCH.sub.3                                                                 "    "                  "                            5-SCH.sub.2 C.sub.6 H.sub.5                                                                 6-NHCOCH.sub.2 CN                                                                        "    "                  "                            5-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                       6-CH.sub.3 "    "                  Na.sup.+                     5-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       "          "    "                  "                            5-SCH.sub.2 CH.sub.2 OH                                                                     "          "    "                  "                            5-SCH.sub.2 CH.sub.2 Cl                                                                     "          "    "                  "                            5-SCH.sub.2 COOC.sub.2 H.sub.5                                                              "          "    "                  "                            5-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                                            "          "    "                  "                            5-SCH.sub.2 C.sub.6 H.sub.11                                                                "          "    "                  "                            5-SO.sub.2 CH.sub.3                                                                         "          "    "                  "                            5-SO.sub.2 C.sub.4 H.sub.9 -n                                                               "          "    "                  "                            5-SO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      6-NHCHO    "    "                  "                            5-SO.sub.2 C.sub.6 H.sub.5                                                                  6-CH.sub.3 "    "                  "                            5-SO.sub.2 C.sub.6 H.sub.11                                                                 "          "    "                  "                            5-SO.sub.2 CH.sub.2 C.sub.6 H.sub.5                                                         "          "    "                  "                            5-SO.sub.2 CH.sub.2 CH.sub.2 OH                                                             "          "    "                  "                             ##STR34##    "          "    "                  "                            5-SCH.sub.2 CH.sub.2 NHCOCH.sub.3                                                           "          "    "                  "                             ##STR35##    "          "    "                  "                            5-SO.sub.2 NH.sub.2                                                                         "          "    "                  "                            5-SO.sub.2 NHC.sub.3 H.sub.6 OCH.sub.3                                                      "          "    CH.sub.2 CH(CH.sub.3)                                                                            "                            5-SO.sub.2 N(CH.sub.3).sub.2                                                                "          "    CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                            5-SO.sub.2 NHC.sub.2 H.sub.5                                                                "          "    CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                            5-SO.sub.2 NHC.sub.6 H.sub.11                                                               "          "    CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                            5-SO.sub.3 C.sub.6 H.sub.5                                                                  "          "    CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                            5-SO.sub.2 NHC.sub.6 H.sub.5                                                                "          "    CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                            5-NHCOCH.sub.3                                                                              "          "    CH.sub.2 CH.sub.2 SCH.sub.2                                                                      "H.sub.2                     5-SC.sub.2 H.sub.5                                                                          "          "    CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                                              "H.sub.2                     "             "          "    CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub                                  .2 CH.sub.2        "                            "             "          "    CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6                                          H.sub.5)CH.sub.2 CH.sub.2                                                                        "                            "             "          "    CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub                                  .2 CH.sub.2        "                            "             "          "    CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                            "             "          "    CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2                                         CH.sub.2 CH.sub.2  "                            "             "          "    CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                            "             "          "    CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                       CH.sub.2 CH.sub.2  "                            "             "          "    CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6                                          H.sub.5)CH.sub.2 CH.sub.2                                                                        "                            "             "          "    CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2                                                        "                            "             "          "    CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                            "             "          "    CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2                                   CH.sub.2          "                            __________________________________________________________________________

                                      TABLE 10                                    __________________________________________________________________________     ##STR36##                                                                    Substituents on                                                               Ring D     (R.sub.1)m R.sub.2      Z                M                         __________________________________________________________________________    3-CH.sub.3 None       C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2                                                                              K.sup.+                   "          "          C.sub.6 H.sub.11                                                                           "                "                         "          "          C.sub.6 H.sub.5                                                                            "                "                         "          3CH.sub.3  C.sub.2 H.sub.5                                                                            "                "                         "          "          CH.sub.2 C.sub.6 H.sub.5                                                                   "                "                         "          "          CH.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                            "                         "          "          CH.sub.2 CH.sub.2 CONH.sub.2                                                               CH.sub.2 CH.sub.2                                                                              "                         3-SCH.sub.3                                                                              "          CH.sub.2 CH.sub.2 Cl                                                                       "                "                         3-C.sub.6 H.sub.5                                                                        3-NHCOCH.sub.3                                                                           C.sub.2 H.sub.5                                                                            "                "                         3-C.sub.6 H.sub.4p-Cl                                                                    2-CH.sub.35-NHCOCH.sub.3                                                                 H            "                "                         3-C.sub.6 H.sub.4o-CN                                                                    2-OCH.sub.35-CH.sub.3                                                                    "            "                "                         "          2-Cl       "            "                "                         "          2-CH.sub.3 "            "                "                         "          2,5-di-Cl  "            "                "                         "          2-OCH.sub.35-Cl                                                                          "            "                "                         "          2-OCH.sub.35-CH.sub.3                                                                    "            "                "                         "          2,5-di-CH.sub.3                                                                          "            "                "                         3-C.sub.6 H.sub.5                                                                        3-CH.sub.3                                                                                ##STR37##   "                "                         "          3-CH.sub.3                                                                                ##STR38##   CH.sub.2 CH(CH.sub.2 Cl)                                                                       "                         "          3-CH.sub.3                                                                                ##STR39##   CH.sub.2 CH.sub.2                                                                              NH.sub.4.sup.+            "          3-CH.sub.3                                                                                ##STR40##   "                K.sup.+                   "          3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                      "                "                         3-C.sub.6 H.sub.4p-CH.sub.2                                                              3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                    "                "                         3-C.sub.6 H.sub.5                                                                        None       CH.sub.3     CH.sub.2 CH.sub.2                                                                              "                         "          3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                           "                         "          "          CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.2 CH.sub.2                                                                              "                         "          "          CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                         "                "                         "          "          CH(CH.sub.3).sub.2                                                                         "                "                         "          H          CH.sub.2 CH.sub.3                                                                          "                K.sup.+                   "          "          CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                 H.sub.5      "                "                         3-SO.sub.2 CH.sub.3                                                                      3-CH.sub.3 CH.sub.2 CH.sub.3                                                                          "                "                         3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                                         "          "            "                "                         3-SCH.sub. 2 C.sub.6 H.sub.5                                                             "          "            "                "                         3-SCH.sub.2 CH.sub.2 OCH.sub.3                                                           "          "            "                "                         3-SC.sub.6 H.sub.11                                                                      3-NHCOC.sub.6 H.sub.5                                                                    "            "                "                         3-SC.sub.2 H.sub.5                                                                       3-NHCONHC.sub.2 H.sub.5                                                                  "            "                "                         "          3-NHCOCH.sub.2 OCH.sub.3                                                                 "            "                "                         "          3-NHCOC.sub.6 H.sub.11                                                                   "            "                "                         "          3-NHCOOC.sub.2 H.sub.5                                                                   "            CH.sub.2 CH(CH.sub.3)                                                                          "                         "          3-NHCOCH.sub.2 CN                                                                        "            CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                "                         3-SCH.sub.2 COOCH.sub.3                                                                  "          "            CH.sub.2 CH.sub.2                                                                              "                         "          None       "            "                "                         "          "          "            "                "                         "          3-CH.sub.3 "            CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                           "                         3-SCH.sub.3                                                                              "          "            CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2 CH.sub.2 CH.sub.2                                                                     "                         "          "          "            CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)C                                       H.sub.2 CH.sub.2 "                         "          "          "            CH.sub.2 CH.sub.2 N(COCH.sub.3)CH.sub.2                                        CH.sub.2        "                         "          "          "            CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2         "                         3-SCH.sub.2 CH(CH.sub.3).sub.2                                                           "          "            CH.sub.2 CH.sub.2                                                                              "                         "          "          "            "                "                         "          "          "            CH.sub.2 CH.sub.2 CONHC.sub.2 H.sub.4                                                          "                         "          "          "            CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                 "                         "          "          "            CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.2                                         CH.sub.2         "                         "          3-NHCOC.sub.6 H.sub.5                                                                    "            CH.sub.2 CH.sub.2                                                                              "                         "          3-NHCOOC.sub.2 H.sub.5                                                                   "            "                "                         "          3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                             "                Na.sup.+                  "          "          C.sub.2 H.sub.5                                                                            CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                              "                         __________________________________________________________________________

                                      TABLE 11                                    __________________________________________________________________________     ##STR41##                                                                    Substituents on                                                               Ring D        (R.sub.1).sub.m                                                                         R.sub.3                                                                          R.sub.4                                                                             Z                  M                         __________________________________________________________________________    3-CH.sub.3    None      CH.sub.3                                                                         CH.sub.3                                                                            CH.sub.2 CH.sub.2  K.sup.+                   "             "         H  CH.sub.3                                                                            "                  "                         "             7-CH.sub.3                                                                              "  "     "                  "                         "             "         CH.sub.3                                                                         "     "                  "                         "             7-CH.sub.3                                                                              H  CH(CH.sub.3).sub.2                                                                  "                  "                         "             7-OCH.sub.3                                                                             "  CH.sub.3                                                                            "                  "                         "             5-OCH.sub.3, 8-CH.sub.3                                                                 "  "     "                  "                         "             5,8-di-OCH.sub.3                                                                        "  "     "                  "                         "             5,8-di-CH.sub.3                                                                         "  "     "                  "                         "             7-Cl      "  "     "                  "                         3-SCH.sub.3   5,8-di-Cl "  "     "                  "                         3-C.sub.6 H.sub.5                                                                           None      "  "     "                  Na.sup.+                  "             5-OCH.sub.3, 8-CH.sub.3                                                                 CH.sub.3                                                                         "     "                  "                         "             7-NHCHO   "  "     "                  "                         "             7-NHCOCH.sub.3                                                                          "  "     "                  "                         "             7-NHCOCH.sub.2 OCH.sub.3                                                                "  "     "                  "                         "             7-NHCOOC.sub.2 H.sub.5                                                                  "  "     "                  "                         "             7-NHCOC.sub.6 H.sub.5                                                                   "  "     "                  "                         "             7-NHCONHC.sub.2 H.sub.5                                                                 "  "     "                  K.sup.+                   "             7-NHCOC.sub.6 H.sub.11                                                                  "  "     "                  "                         "             None      "  "     "                  "                         "             7-CH.sub.3                                                                              H  "     "                  "                         C.sub.6 H.sub.4o-CN                                                                         "         "  H     "                  "                         "             "         "  CH.sub.3                                                                            "                  "                         "             "         "  "     "                  "                         "             "         "  "     "                  "                         3-C.sub.6 H.sub.4p-CH.sub.3                                                                 "         "  "     "                  "                         3-C.sub.6 H.sub.4o-Cl                                                                       "         "  "     "                  "                         3-SO.sub.2 CH.sub.3                                                                         7-OCH.sub.3                                                                             "  "     "                  "                         3-SC.sub.6 H.sub.11                                                                         7-CH.sub.3                                                                              "  "     "                  "                         3-SCH.sub.2 CH.sub.2 OCH.sub.3                                                              "         "  "     "                  "                         3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                                            "         "  "     "                  "                         3-SCH.sub.2 C.sub.6 H.sub.5                                                                 "         "  "     "                  "                         3-CH.sub.2 CH.sub.3                                                                         "         "  "     "                  "                         3-SCH.sub.2 COOCH.sub.3                                                                     "         "  "     "                  "                         3-SCH.sub.2 CH.sub.2 COOC.sub.2 H.sub.5                                                     None      "  "     "                  "                         3-SCH.sub.2 CH.sub.2 COOCH(CH.sub.3).sub.2                                                  "         "  "     "                  "                         3-SO.sub.2 C.sub.4 H.sub.9 -n                                                               "         "  "     "                  "                         3-SCH.sub.2 CH.sub.2 CONHC.sub.4 H.sub.9 -n                                                 "         "  "     "                  "                         3-SCH.sub.3   7-CH.sub.3                                                                              "  "     "                  "                         "             "         "  "     "                  "                         3-SC.sub.2 H.sub.5                                                                          "         "  "     CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                         "             "         "  "     CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                         "             "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2           "                         "             "         "  "     CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.                                     sub.2 CH.sub.2     "                         "             "         "  "     CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2           "                         "             "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                          "                         "             "         "  "     CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                         "             "         "  "     CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)CH.                                     sub.2 CH.sub.2     "                         "             "         "  "     CH.sub.2 CH.sub.2 (CH.sub.3)                                                                     "                         "             "         "  "     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+                  "             "         "  "     CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                         "             "         "  "     CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                         "             "         "  "     CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                         "             "         "  "     CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                         "             "         "  "     CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)SO.                                     sub.2 CH.sub.2 CH.sub.2                                                                          "                         "             "         "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                         __________________________________________________________________________

                                      TABLE 12                                    __________________________________________________________________________     ##STR42##                                                                    Substituents on                                                               Ring D        (R.sub.1)m                                                                              R.sub.3                                                                           Z                  M                              __________________________________________________________________________    3-CH.sub.3    None      H   CH.sub.2 CH.sub.2  Na.sup.+                       "             6-CH.sub.3                                                                              "   "                  "                              "             "         3-CH.sub.3                                                                        "                  "                              "             6-OCH.sub.3                                                                             "   "                  "                              "             "         H   "                  "                              "             6-CH.sub.3                                                                              3-CH.sub.3                                                                        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                              "                              3-SCH.sub.3   "         "   CH.sub.2 CH.sub.2  "                              3-CH.sub.2 CH.sub.3                                                                         "         "   "                  "                              3-SCH.sub.2 CH.sub.2 OCH.sub.3                                                              "         "   "                  "                              3-SCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                                       "         "   "                  "                              3-SCH.sub.2 CH.sub.2 COOCH.sub.3                                                            "         "   "                  "                              3-SCH.sub.2 COOCH.sub.2 CH.sub.3                                                            "         "   "                  "                              3-SCH.sub.2 C.sub.6 H.sub.5                                                                 "         "   "                  "                              3-SC.sub.6 H.sub.11                                                                         "         "   "                  "                              3-SCH.sub.3   6-NHCOCH.sub.3                                                                          "   "                  K.sup.+                        "             6-NHCOC.sub.6 H.sub.5                                                                   "   "                  "                              "             6-NHCOC.sub.4 H.sub.9n                                                                  "   "                  "                              "             6-NHCONHC.sub.2 H.sub.5                                                                 "   "                  "                              "             6-NHCOCH.sub.2 OCH.sub.3                                                                "   "                  "                              "             6-NHCOCH.sub.2 CN                                                                       "   "                  "                              3-SO.sub.2 CH.sub.3                                                                         6-CH.sub.3                                                                              "   "                  Na.sup.+                       3-SO.sub.2 C.sub.4 H.sub.9n                                                                 "         "   "                  "                              3-C.sub.6 H.sub.5                                                                           "         "   "                  "                              3-C.sub.6 H.sub.4o-CN                                                                       "         "   "                  "                              3-C.sub.6 H.sub.4o-Cl                                                                       "         "   "                  "                              3-C.sub.6 H.sub.4p-CH.sub.3                                                                 "         "   "                  "                              3-C.sub.6 H.sub.4m-CH.sub.3                                                                 "         "   "                  "                              3-C.sub.6 H.sub.4o-CH.sub.3                                                                 "         "   "                  "                              3-C.sub.6 H.sub.4o-CONH.sub.2                                                               "         "   "                  "                              3-C.sub.6 H.sub.4OCN                                                                        6-NHCHO   "   "                  "                              3-SCH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                       6-CH.sub.3                                                                              "   "                  "                              3-SO.sub.2 C.sub.4 H.sub.9 -n                                                               "         "   "                  "                              3-SO.sub.2 CH.sub.2 CH.sub.2 COOCH.sub.3                                                    "         "   "                  "                              3-SO.sub.2 CH.sub.2 COOCH.sub.3                                                             "         "   "                  "                              3-SO.sub.2 C.sub.6 H.sub.11                                                                 "         "   "                  "                              3-SO.sub.2 CH.sub.2 CH.sub.3                                                                "         "   "                  "                              3-SO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      "         "   "                  "                              3-SCH.sub.2 CH.sub.2 CONHC.sub.2 H.sub.4 OH                                                 "         "   "                  "                              3-SCH.sub.2 CH.sub.3                                                                        "         "   CH.sub.2 CH(CH.sub.3)                                                                            "                              "             "         "   CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                              "             "         "   CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                              "             "         "   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                              "             "         "   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                              "             "         "   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                              "             "         "   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                              3-C.sub.6 H.sub.5                                                                           "         "   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2                                                     "                              "             "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.sub.2                                 CH.sub.2          "                              "             "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6 H.sub.5)C                                H.sub.2 CH.sub.2   "                              "             "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.sub.2                                 CH.sub.2          "                              "             "         "   CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                              "             "         "   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2                                         CH.sub.2 CH.sub.2  "                              "             "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                              "             "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                       CH.sub.2 CH.sub.2  "                              "             "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6 H.sub.5)C                                H.sub.2 CH.sub.2   "                              "             "         "   CH.sub.2 CH.sub.2 NHCONHCH.sub.2 CH.sub.2                                                        "                              "             "         "   CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                              "             "         "   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.sub.2                                  CH.sub.2           "                              __________________________________________________________________________

                                      TABLE 13                                    __________________________________________________________________________     ##STR43##                                                                    Substituents on                                                               Ring E          (R.sub.1)m                                                                              R.sub.2        Z                 M                  __________________________________________________________________________    3-CH.sub.34-Br  None      C.sub.2 H.sub.5                                                                              CH.sub.2 CH.sub.2 K.sup.+            "               "         C.sub.6 H.sub.11                                                                             "                 "                  "               "         C.sub.6 H.sub.5                                                                              "                 "                  "               3CH.sub.3 C.sub.2 H.sub.5                                                                              "                 "                  "               "         CH.sub.2 C.sub.6 H.sub.5                                                                     "                 "                  "               "         CH.sub.2 CH.sub.2 OCH.sub.3                                                                  CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2          "                  "               "         CH.sub.2 CH.sub.2 CONH.sub.2                                                                 CH.sub.2 CH.sub.2 "                  "               "         CH.sub.2 CH.sub.2 Cl                                                                         "                 "                  "               3-NHCOCH.sub.3                                                                          C.sub.2 H.sub.5                                                                              "                 "                  "               2-CH.sub.35-NHCOCH.sub.3                                                                H              "                 "                  "               2-OCH.sub.35-.sub.3                                                                     "              "                 "                  "               2-Cl      "              "                 "                  "               2-CH.sub.3                                                                              "              "                 "                  "               2,5-di-Cl "              "                 "                  "               2-OCH.sub.3 -5-Cl                                                                       "              "                 "                  3-CH.sub.3 -4-Cl                                                                              2-OCH.sub.35-CH.sub.3                                                                   "              "                 "                  "               2,5-di-CH.sub.3                                                                         "              "                 Na.sup.+           "               3-CH.sub.3                                                                               ##STR44##     "                 "                  "               3-CH.sub.3                                                                               ##STR45##     CH.sub.2 CH(CH.sub.2 Cl)                                                                        "                  3-CH.sub.34-CN  3-CH.sub.3                                                                               ##STR46##     CH.sub.2 CH.sub.2 NH.sub.4.sup.+     3-CH.sub.34-COOC.sub.2 H.sub.5                                                                3-CH.sub.3                                                                               ##STR47##     "                 K.sup.+            "               3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                        "                 "                  "               3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                      "                 "                  "               None      CH.sub.3       CH.sub.2 CH.sub.2 "                  3-CH.sub.34-SCH.sub.2 CHCH.sub.2                                                              3-CH.sub.3                                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                                  CH.sub.2 CH.sub.2 OCH.sub.2                                                                     "H                 "               "         CH.sub.2 C.sub.6 H.sub.11                                                                    CH.sub.2 CH.sub.2 "                  "               "         CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                           "                 "                  3-CH.sub.34-SO.sub.2 C.sub.2 H.sub.5                                                          "         CH(CH.sub.3).sub.2                                                                           "                 "                  3-CH.sub.34-SC.sub.6 H.sub.11                                                                 H         CH.sub.2 CH.sub.3                                                                            "                 K.sup.+            3-CH.sub.34-OC.sub.2 H.sub.5                                                                  "         CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OC.sub.2                                 H.sub.5        "                 "                  3-Cl4-CN        3-CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                            "                 "                  3-CH.sub.34-SCN "         "              "                 "                  3-Br4-COOCH.sub.3                                                                             "         "              "                 "                  3-CH.sub.34-COOC.sub.2 H.sub.5                                                                "         "              "                 "                  3-CH.sub.34-CONH.sub.2                                                                        3-NHCOC.sub.6 H.sub.5                                                                   "              "                 "                  3-CH.sub.34-CONHC.sub.2 H.sub.4 OH                                                            3-NHCONHC.sub.2 H.sub.5                                                                 "              "                 "                  3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                                            3-NHCOCH.sub.2 OCH.sub.3                                                                "              "                 "                  3-CH.sub.34-OC.sub.6 H.sub.5                                                                  3-NHCOC.sub.6 H.sub.11                                                                  "              "                 "                  3-CH.sub.34-OC.sub.6 H.sub.4 p-CH.sub.3                                                       3-NHCOOC.sub.2 H.sub.5                                                                  "              CH.sub.2 CH(CH.sub.3)                                                                           "                  3-CH.sub.34-SC.sub.6 H.sub.5                                                                  3-NHCOCH.sub.2 CN                                                                       "              CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                 "                  3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                                             "         "              CH.sub.2 CH.sub.2 "                  3-CH.sub.34-SCH.sub.2 CH.sub.3                                                                None      "              "                 "                   ##STR48##      "         "              "                                    3-CH.sub.34-Br  3-CH.sub.3                                                                              "              CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2          "                  "               "         "              CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2          "                  "               "         "              CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                      "                  "               "         "              CH.sub.2 CH.sub.2 N(COCH.sub.3)CH                                             .sub.2 CH.sub.2   "                  "               "         "              CH.sub.2 CH.sub.2 SO.sub.2                                                    NHCH.sub.2 CH.sub.2                                                                             "                  3-CH.sub.34-CONH.sub.2                                                                        "         "              CH.sub.2 CH.sub.2 "                  3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                                     "         "              "                 "                  3-CH.sub.34-Cl  "         "              CH.sub.2 CH.sub.2 CONHC.sub.2                                                 H.sub.4           "                  "               "         "              CH.sub.2 CH.sub.2                                                                               "HCOCH.sub.2       "               "         "              CH.sub.2 CH.sub.2 NHSO.sub.2                                                  CH.sub.2 CH.sub.2 "                  "               3-NHCOC.sub.6 H.sub.5                                                                   "              CH.sub.2 CH.sub.2 "                  "               3-NHCOOC.sub.2 H.sub.5                                                                  "              "                 "                  "               3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                               "                 Na.sup.+           "               "         C.sub.2 H.sub.5                                                                              CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                               "                  __________________________________________________________________________

                                      TABLE 14                                    __________________________________________________________________________     ##STR49##                                                                    Substituents on                                                               Ring E         (R.sub.1).sub.m                                                                         R.sub.3                                                                          R.sub.4                                                                                Z                 M                      __________________________________________________________________________    3-CH.sub.34-Br None      CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 CH.sub.2   K.sup.+                  "              "       H  CH.sub.3                                                                               "                 "                        "            7-CH.sub.3                                                                              "  "        "                 "                        "              "       CH.sub.3                                                                         "        "                 "                        "            7-CH.sub.3                                                                              H  CH(CH.sub.3).sub.2                                                                      "                "                        "            7-OCH.sub.3                                                                             "  CH.sub.3                                                                               "                 "                        "            5-OCH.sub.3, 8-CH.sub.3                                                                 "  "        "                 "                        "            5,8-di-OCH.sub.3                                                                        "  "        "                 "                        "            5,8-di-CH.sub.3                                                                         "  "        "                 "                        "            7-Cl      "  "        "                 "                        "            5,8-di-Cl "  "        "                 "                      3-CH.sub.34-CN None      "  "        "                 Na.sup.+                 "            5-OCH.sub.3, 8-CH.sub.3                                                                 CH.sub.3                                                                         "        "                 "                        "            7-NHCHO   "  "        "                 "                      3-CH.sub.34-COOC.sub.2 H.sub.5                                                               7-NHCOCH.sub.3                                                                          "  "        "                 "                        "            7-NHCOCH.sub.2 OCH.sub.3                                                                "  "        "                 "                        "            7-NHCOOC.sub.2 H.sub.5                                                                  "  "        "                 "                      3-CH.sub.3     7-NHCOC.sub.6 H.sub.5                                                                   "  "        "                 "                        "            7-NHCONHC.sub.2 H.sub.5                                                                 "  "        "                 K.sup.+                3-CH.sub.34-Cl 7-NHCOC.sub.6 H.sub.11                                                                  "  "        "                 "                        "            None      "  "        "                 "                        "            7-CH.sub.3                                                                              H  "        "                 "                        "              "       "  H        "                 "                      3-Cl4-CN         "       "  CH.sub.3                                                                               "                 "                      3-Br4-COOCH.sub.3                                                                              "       "  "        "                 "                      3-CH.sub.34-COOCH.sub.3                                                                        "       "  "        "                 "                      3-CH.sub.34-CONH.sub.2                                                                         "       "  "        "                 "                      3-CH.sub.34-COOCHC.sub.2 H.sub.4 OH                                                            "       "  "        "                 "                      3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                                           7-OCH.sub.3                                                                             "  "        "                 "                      3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                                    7-CH.sub.3                                                                              "  "        "                 "                      3-CH.sub.34-COOC.sub.2 H.sub.4 OCH.sub.3                                                       "       "  "        "                 "                      3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                                              "       "  "        "                 "                      3-CH.sub.34-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                                     "       "  "        "                 "                      3-CH.sub.34-SCH.sub.3                                                                          "       "  "        "                 "                      3-CH.sub.34-SO.sub.2 CH.sub.3                                                                  "       "  "        "                 "                      3-CH.sub.34-SC.sub.6 H.sub.5                                                                 None      "  "        "                 "                      3-CH.sub.34-SC.sub.6 H.sub.4p-C(CH.sub.3).sub.3                                                "       "  "        "                 "                      3-CH.sub.34-SC.sub.6 H.sub.4p-Cl                                                               "       "  "        "                 "                       ##STR50##       "       "  "        "                 "                       ##STR51##     7-CH.sub.3                                                                              "  "        "                 "                       ##STR52##       "       "  "        "                 "                      3-CH.sub.3SC.sub.6 H.sub.11                                                                    "       "  "      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                              "                      3-CH.sub.34-SCN                                                                                "       "  "      CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                              "                      3-CH.sub.34-OC.sub.6 H.sub.5                                                                   "       "  "      CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2            "                      3-CH.sub.34-OC.sub.2 H.sub.5                                                                    "      "  "      CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)C                                       H.sub.2 CH.sub.2    "                      3-CH.sub.34-SCH.sub.2 CHCH.sub.2                                                               "       "  "      CH.sub.2 CH.sub.2 SO.sub.2 NHCH.sub.2                                         CH.sub.2            "                      3-CH.sub.34-Br   "       "  "      CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                           "                        "              "       "  "      CH.sub.2 CH.sub.2 CONHCH.sub.2                                                                    "H.sub.2                 "              "       "  "      CH.sub.2 CH.sub.2 N(COC.sub.6 H.sub.5)C                                       H.sub.2 CH.sub.2    "                        "              "       "  "      CH.sub.2 CH.sub.2 (CH.sub.3)                                                                      "                        "              "       "  "      CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                 Na.sup.+                 "              "       "  "      CH.sub.2 CH(CH.sub.2)Cl                                                                           "                        "              "       "  "      CH.sub.2 CH(C.sub.6 H.sub.5)                                                                      "                        "              "       "  "      CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                            "                        "              "       "  "      CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.3)S                                       O.sub.2 CH.sub.2 CH.sub.2                                                                         "                        "              "       "  "      CH.sub.2 CH.sub.2 CH.sub.2                                                                        "                      __________________________________________________________________________

                                      TABLE 15                                    __________________________________________________________________________     ##STR53##                                                                    Substituents on                                                               Ring E             (R.sub.1).sub.m                                                                         R.sub.3                                                                             Z                M                         __________________________________________________________________________    3-CH.sub.2Cl       None      H   CH.sub.2 CH.sub.2  Na.sup.+                    "                6-CH.sub.3                                                                              "     "                "                           "                  "       3-CH.sub.3                                                                          "                "                           "                6-OCH.sub.3                                                                             "     "                "                         3-Cl4-CN             "       H     "                "                           "                6-CH.sub.3                                                                              3-CH.sub.3                                                                        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                              "                         3-CH.sub.3           "       "   CH.sub.2 CH.sub.2  "                         3-CH.sub.34-COOC.sub.2 H.sub.5                                                                     "       "     "                "                         3-CH.sub.34-CONH.sub.2                                                                             "       "     "                "                         3-CH.sub.34-CONHC.sub.2 H.sub.4 OH                                                                 "       "     "                "                         3-CH.sub.34-CONHC.sub.4 H.sub.9 -n                                                                 "       "     "                "                         3-CH.sub.34-CONHC.sub.3 H.sub.6 OCH.sub.3                                                          "       "     "                "                         3-CH.sub.34-CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                   "       "     "                "                         3-CH.sub.34-CONHCH.sub.3                                                                           "       "     "                "                         3-CH.sub.34-Br     6-NHCOCH.sub.3                                                                          "     "                K.sup.+                     "                6-NHCOC.sub.6 H.sub.5                                                                   "     "                "                           "                6-NHCOC.sub.4 H.sub.9 -n                                                                "     "                "                           "                6-NHCONHC.sub.2 H.sub.5                                                                 "     "                "                           "                6-NHCOCH.sub.2 OCH.sub.3                                                                "     "                "                           "                6-NHCOCH.sub.2 CN                                                                       "     "                "                         3-CH.sub.34-SC.sub.2 H.sub.5                                                                     6-CH.sub.3                                                                              "     "                Na.sup.+                  3-CH.sub.34-SCH.sub.2 CH.sub.2 OH                                                                  "       "     "                "                         3-CH.sub.34-SCH.sub.3 CHCH.sub.2                                                                   "       "     "                "                         3-CH.sub.34-SCH.sub.2 CH.sub.2 OCOCH.sub.3                                                         "       "     "                "                         3-CH.sub.34-SC.sub.6 H.sub.5                                                                       "       "     "                "                         3-CH.sub.34-SC.sub.6 H.sub.4 -p-C(CH.sub.3).sub.2                                                  "       "     "                "                         3-CH.sub.34-SC.sub.6 H.sub.11                                                                      "       "     "                "                         3-CH.sub.34-SO.sub.2 CH.sub.2 CH.sub.2 OH                                                          "       "     "                "                         3-CH.sub.34-SO.sub. 2 CH.sub.2 CH.sub.3                                                            "       "     "                "                         3-CH.sub.34-OC.sub.6 H.sub.5                                                                     6-NHCHO   "     "                "                         3-CH.sub.34-OC.sub.6 H.sub.4 -p-OCH.sub.3                                                        6-CH.sub.3                                                                              "     "                "                          ##STR54##           "       "     "                "                          ##STR55##           "       "     "                "                          ##STR56##           "       "     "                "                         3-CH.sub.3-SCH.sub.2 CH(OH)CH.sub.2 OH                                                             "       "     "                "                         3-CH.sub.34-SCH.sub.2 COOCH.sub.3                                                                  "       "     "                "                         3-CH.sub.34-OC.sub.2 H.sub.5                                                                       "       "     "                "                         3-CH.sub.34-Br       "       "     "                "                           "                  "       "   CH.sub.2 CH(CH.sub.3)                                                                            "                           "                  "       "   CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                           "                  "       "   CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                           "                  "       "   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                           "                  "       "   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                           "                  "       "   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                           "                  "       "   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                           "                  "       "   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub. 2                                          CH.sub.2           "                           "                  "       "   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.                                     sub.2 CH.sub.2     "                           "                  "       "   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6                                          H.sub.5)CH.sub.2 CH.sub.2                                                                        "                           "                  "       "   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.                                     sub.2 CH.sub.2     "                           "                  "       "   CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                           "                  "       "   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2                                         CH.sub.2 CH.sub.2  "                           "                  "       "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                           "                  "       "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                       CH.sub.2 CH.sub.2  "                           "                  "       "   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6                                          H.sub. 5)CH.sub.2 CH.sub.2                                                                       "                           "                  "       "   CH.sub.2 CH.sub.2 NHCONHCH.sub.2                                                                 "H.sub.2                    "                  "       "   CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                           "                  "       "   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.su                                     b.2 CH.sub.2       "                         __________________________________________________________________________

                                      TABLE 16                                    __________________________________________________________________________     ##STR57##                                                                           Substituents on                                                        A      Ring F     (R.sub.1).sub.m                                                                          R.sub.2       Z               M                  __________________________________________________________________________    H      4-CN       None       C.sub.2 H.sub.5                                                                             CH.sub.2 CH.sub.2                                                                             K.sup.+              "      "          "        C.sub.6 H.sub.11                                                                              "             "                    "      "          "        C.sub.6 H.sub.5                                                                               "             "                    "      "        3-CH.sub.3 C.sub.2 H.sub.5                                                                               "             "                    "      "          "        CH.sub.2 C.sub.6 H.sub.5                                                                      "             "                    "      "          "        CH.sub.2 CH.sub.2 OCH.sub.3                                                                 CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2        "                    "      "          "        CH.sub.2 CH.sub.2 CONH.sub.2                                                                CH.sub.2 CH.sub.2                                                                             "                    "      "          "        CH.sub.2 CH.sub.2 Cl                                                                          "             "                    "      "        3-NHCOCH.sub.3                                                                           C.sub.2 H.sub.5                                                                               "             "                    "      "        2-CH.sub.35-NHCOCH.sub.3                                                                 H               "             "                    "      "        2-OCH.sub.35-CH.sub.3                                                                    "               "             "                    "      "        2-Cl       "               "             "                    "      "        2-CH.sub.3 "               "             "                    "      "        2,5-di-Cl  "               "             "                    "      "        2-OCH.sub. 35-Cl                                                                         "               "             "                    "      "        2-OCH.sub.35-CH.sub.3                                                                    "               "             "                  C.sub.6 H.sub.5                                                                      3-SC.sub.2 H.sub.54-CN                                                                   2,5-di-CH.sub.3                                                                          "               "             Na.sup.+             "    3-SC.sub.2 H.sub.54-COOCH.sub.3                                                          3-CH.sub.3                                                                                ##STR58##      "             "                    "    3-SC.sub.2 H.sub.54-CONH.sub.2                                                           3-CH.sub.3                                                                                ##STR59##    CH.sub.2 CH(CH.sub.2 Cl)                                                                      "                    "    3-SCH.sub.34-CN                                                                          3-CH.sub.3                                                                                ##STR60##    CH.sub.2 CH.sub.2                                                                             NH.sub.4.sup.+       "      "        3-CH.sub.3                                                                                ##STR61##      "             K.sup.+              "      "        3-CH.sub.3 CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                         "             "                    "      "        3-CH.sub.3 CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                       "             "                  SO.sub.2 C.sub.6 H.sub.5                                                               "        None       CH.sub.3      CH.sub.2 CH.sub.2                                                                             "                  COCH.sub.3                                                                           4-CN       3-CH.sub.3 CH.sub.2 CH(CH.sub.3).sub.2                                                                 CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2        "                  H        "          "        CH.sub.2 C.sub.6 H.sub.11                                                                   CH.sub.2 CH.sub.2                                                                             "                    "      "          "        CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                            "             "                    "      "          "        CH(CH.sub.3).sub.2                                                                            "             "                  COOC.sub.2 H.sub.5                                                                     "        H          CH.sub.2 CH.sub.3                                                                             "             K.sup.+            H        "          "        CH.sub.2 CH.sub. 2 OCH.sub.2 CH.sub.2                                         OC.sub.2 H.sub.5                                                                              "             "                  CH.sub.3                                                                             4-CN       3-CH.sub.3 CH.sub.2 CH.sub.3                                                                             "             "                    "    4-COOCH.sub.3                                                                              "          "             "             "                    "    4-CONH.sub.2                                                                               "          "             "             "                  CH.sub.2 CH.sub.3                                                                    4-CN         "          "             "             "                  C.sub.2 H.sub.5                                                                        "        3-NHCOC.sub.6 H.sub.5                                                                      "             "             "                    "    4-COOCH.sub.3                                                                            3-NHCONHC.sub.2 H.sub.5                                                                    "             "             "                  C.sub.6 H.sub.4 -p-Cl                                                                  "        3-NHCOCH.sub.2 OCH.sub.3                                                                   "             "             "                  C.sub.6 H.sub.4 -o-CH.sub.3                                                            "        3-NHCOC.sub.6 H.sub.11                                                                     "             "             "                  C.sub.6 H.sub.5                                                                        "        3-NHCOOC.sub.2 H.sub.5                                                                     "           CH.sub.2 CH(CH.sub.3)                                                                         "                     "     "        3-NHCOCH.sub.2 N                                                                           "           CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                               "                  H      4-CONHC.sub.2 H.sub.4 OH                                                                   "          "           CH.sub.2 CH.sub.2                                                                             "                    "    4-CONHC.sub.4 H.sub.9 -n                                                                 None         "             "             "                    "    4-COOC.sub.2 H.sub.4 OCH.sub.3                                                             "          "             "             "                    "    4-CONHC.sub.3 H.sub.6 OCH.sub.3                                                          3-CH.sub.3   "           CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2        "                    "    4-CN         "          "           CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2                                                                      CH.sub.2 CH.sub.2 CH.sub.2                                                                    "                    "      "          "          "           CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                    "                    "      "          "          "           CH.sub.2 CH.sub.2 N(COCH.sub.3)                                               CH.sub.2 CH.sub.2                                                                             "                    "      "          "          "           CH.sub.2 CH.sub.2 SO.sub.2                                                    NHCH.sub.2 CH.sub.2                                                                           "                  SO.sub.2 CH.sub.3                                                                    4-CN         "          "           CH.sub.2 CH.sub.2                                                                             "                  SO.sub.2 C.sub.6 H.sub.5                                                               "          "          "             "             "                  SO.sub.2 CH.sub.2 CH.sub.3                                                             "          "          "           CH.sub.2 CH.sub.2 CONHC.sub.2                                                 H.sub.4         "                  H        "          "          "           CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                "                    "      "          "          "           CH.sub.2 CH.sub.2 NHSO.sub.2                                                  CH.sub.2 CH.sub.2                                                                             "                    "      "        3-NHCOC.sub.6 H.sub.5                                                                      "           CH.sub.2 CH.sub.2                                                                             "                    "      "        3-NHCOOC.sub.2 H.sub. 5                                                                    "             "             "                    "      "        3-CH.sub.3 CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                                "             Na.sup.+             "      "          "        C.sub.2 H.sub.5                                                                             CH.sub.2 CH(OSO.sub.3 Na)CH.sub                                               .2              "                  __________________________________________________________________________

                                      TABLE 17                                    __________________________________________________________________________     ##STR62##                                                                            Substituents on                                                       A       Ring F      (R.sub.1).sub.m                                                                          R.sub.3                                                                          R.sub.4                                                                               Z                M                  __________________________________________________________________________    H       4-CN        None       CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 CH.sub.2 K.sup.+            "         "           "        H  CH.sub.3                                                                              "                "                  "         "         7-CH.sub.3 "  "       "                "                  "         "           "        CH.sub.3                                                                         "       "                "                  "         "         7-CH.sub.3 H  CH(CH.sub.3).sub.2                                                                    "                "                  "         "         7-OCH.sub.3                                                                              "  CH.sub.3                                                                              "                "                  "         "         5-OCH.sub.3, 8-CH.sub.3                                                                  "  "       "                "                  "         "         5,8-di-OCH.sub.3                                                                         "  "       "                "                  "         "         5,8-di-CH.sub.3                                                                          "  "       "                "                  "         "         7-Cl       "  "       "                "                  "         "         5,8-di-Cl  "  "       "                "                  CH.sub.3                                                                                "         None       "  "       "                Na.sup.+           "         "         5-OCH.sub.3, 8-CH.sub.3                                                                  CH.sub.3                                                                         "       "                "                  H       4-COOCH.sub.3                                                                             7-NHCHO    "  "       "                "                  H       4-COOC.sub.2 H.sub.5                                                                      7-NHCOCH.sub.3                                                                           "  "       "                "                  H       4-COOC.sub. 2 H.sub.4 OCH.sub.3                                                           7-NHCOCH.sub.2 OCH.sub.3                                                                 "  "       "                "                  H       4-CONH.sub.2                                                                              7-NHCOOC.sub.2 H.sub.5                                                                   "  "       "                "                  H       4-CONHC.sub.2 H.sub.5                                                                     7-NHCOC.sub.6 H.sub.5                                                                    "  "       "                "                  "         "         7-NHCONHC.sub.2 H.sub.5                                                                  "  "       "                K.sup.+            "         "         7-NHCOC.sub.6 H.sub.11                                                                   "  "       "                "                  C.sub.6 H.sub.5                                                                       4-CN        None       "  "       "                "                  "         "         7-CH.sub.3 H  "       "                "                  C.sub.6 H.sub.4 -p-Cl                                                                   "           "        "  H       "                "                  C.sub.6 H.sub.4 -p-CH.sub.3                                                             "           "        "  CH.sub.3                                                                              "                "                  SO.sub.2 CH.sub.3                                                                       "           "        "  "       "                "                  "       4-COOCH.sub. 3                                                                              "        "  "       "                "                  SO.sub.2 C.sub.6 H.sub.5                                                                "           "        "  "       "                "                  "       4-CN          "        "  "       "                "                  "       4-CONH.sub.2 H.sub.4 OH                                                                   7-OCH.sub.3                                                                              "  "       "                "                  "       4-COOCH(CH.sub.3).sub.2                                                                   7-CH.sub.3 "  "       "                "                  CH.sub.3                                                                              3-SC.sub.2 H.sub.5 -4-CN                                                                    "        "  "       "                "                  C.sub.6 H.sub.5                                                                         "           "        "  "       "                "                  "       3-SC.sub.2 H.sub.5 -4-COOCH.sub.3                                                           "        "  "       "                "                  "       3-SCH.sub.3 -4-COOC.sub.2 H.sub.5                                                           "        "  "       "                "                  "       3-SO.sub.2 CH.sub.3 -4-COOCH.sub.3                                                          "        "  "       "                "                  "       3-SC.sub.6 H.sub.5 -4-COOCH.sub.3                                                         None       "  "       "                "                  COCH.sub.3                                                                            4-CN          "        "  "       "                "                  "       4-COOCH.sub.3                                                                               "        "  "       "                "                  CH.sub.2 CH.sub.2 OH                                                                    "           "        "  "       "                "                  H       3-CH.sub.2 CN-4-CN                                                                        7-CH.sub.3 "  "       "                "                  H       3-CH.sub.2 CONH.sub.2 -4-CN                                                                 "        "  "       "                "                  H       4-CN          "        "  "     CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2           "                  "         "           "        "  "     CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2           "                  "         "           "        "  "     CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2 CH.sub.2  "                  "         "           "        "  "     CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                       "                  "         "           "        "  "     CH.sub.2 CH.sub.2 SO.sub.2                                                    NHCH.sub.2 CH.sub.2                                                                              "                  "         "           "        "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                    NHCOCH.sub.2       "                  "         "           "        "  "     CH.sub.2 CH.sub.2 CONHCH.sub.2                                                CH.sub.2           "                  "         "           "        "  "     CH.sub.2 CH.sub.2 N(COC.sub.6                                                 H.sub.5)CH.sub.2 CH.sub.2                                                                        "                  "         "           "        "  "     CH.sub.2 CH.sub.2 (CH.sub.3).sub.2                                                               "                  "         "           "        "  "     CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+           "         "           "        "  "     CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                  "         "           "        "  "     CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                  "         "           "        "  "     CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                  "         "           "        "  "     CH.sub.2 CH(CH.sub.2 OC.sub.6                                                 H.sub.5)           "                  "         "           "        "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                    N(CH.sub.3)SO.sub.2 CH.sub.2                                                  CH.sub.2           "                  "         "           "        "  "     CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                  __________________________________________________________________________

                                      TABLE 18                                    __________________________________________________________________________     ##STR63##                                                                              Substituents                                                        A         on Ring F      (R.sub.1).sub.m                                                                          R.sub.3                                                                            Z                  M                 __________________________________________________________________________    H         4-CN           None       H    CH.sub.2 CH.sub.2  Na.sup.+          "         "              6-CH.sub.3 "    "                  "                 CH.sub.3  "              "          3-CH.sub.3                                                                         "                  "                 "         4-COOCH.sub.3  6-OCH.sub.3                                                                              "    "                  "                 "         4-COOC.sub.2 H.sub.4 OC.sub.2 H.sub.5                                                        "          H    "                  "                 "         4-CONH.sub.2   6-CH.sub.3 3-CH.sub.3                                                                         CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2           "                 "         4-CONHC.sub.2 H.sub.4 OH                                                                     "          "    CH.sub.2 CH.sub.2  "                 "         4-CONHC.sub.3 H.sub.6 OCH.sub.3                                                              "          "    "                  "                 "         4-CONHC.sub.2 H.sub.4 NHCOCH.sub.3                                                           "          "    "                  "                 CH.sub.2 CH.sub.3                                                                       4-CN           "          "    "                  "                 C.sub.6 H.sub.5                                                                         "              "          "    "                  "                 "         4-COOCH.sub.2 CH.sub.3                                                                       "          "    "                  "                 "         4-CONH.sub.2   "          "    "                  "                 C.sub.6 H.sub.4 -o-Cl                                                                   "              "          "    "                  "                 H         "              6-NHCOCH.sub. 3                                                                          "    "                  K.sup.+           "         4-COOCH.sub.3  6-NHCOC.sub.6 H.sub.5                                                                    "    "                  "                 "         "              6-NHCOC.sub.4 H.sub.9 -n                                                                 "    "                  "                 "         4-CONHC.sub.4 H.sub. 9 -n                                                                    6-NHCONHC.sub.2 H.sub.5                                                                  "    "                  "                 "         "              6-NHCOCH.sub.2 OCH.sub.3                                                                 "    "                  "                 "         "              6-NHCOCH.sub.2 CN                                                                        "    "                  "                 SO.sub.2 CH.sub.3                                                                       HCN            6-CH.sub.3 "    "                  Na.sup.+          "         4-COOCH.sub.3  "          "    "                  "                 H         3-CH.sub. 2 CN-4-CN                                                                          "          "    "                  "                 C.sub.6 H.sub.5                                                                         3-SCH.sub.3 -4-CN                                                                            "          "    "                  "                 "         3-SCH.sub.2 CH.sub.3 -4-CN                                                                   "          "    "                  "                 "         3-SCH.sub.2 CH.sub.3 -4-COOCH.sub. 3                                                         "          "    "                  "                 "         3-SCH.sub.3 -4-CONHC.sub. 4 H.sub.9 -n                                                       "          "    "                  "                 SO.sub.2 C.sub.6 H.sub.5                                                                4-CN           "          "    "                  "                 "         4-COOCH.sub.3  "          "    "                  "                 SO.sub.2 C.sub.6 H.sub.4 -p-CH.sub. 3                                                   4-CN           6-NHCHO    "    "                  "                 SO.sub.2 C.sub.4 H.sub.9 -n                                                             "              6-CH.sub.3 "    "                  "                 COCH.sub.3                                                                              "              "          "    "                  "                 COOC.sub.2 H.sub.5                                                                      "              "          "    "                  "                 CH.sub.2 CH.sub.2 OH                                                                    "              "          "    "                  "                 C.sub.6 H.sub.4OCH.sub.3                                                                "              "          "    "                  "                 "         4-COOCH.sub.3  "          "    "                  "                 "         4-COOCH(CH.sub.3).sub.2                                                                      "          "    "                  "                 SO.sub.2 C.sub.6 H.sub.11                                                               "              "          "    "                  "                 H         4-CN           "          "    CH.sub.2 CH(CH.sub.3)                                                                            "                 "         "              "          "    CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                 "         "              "          "    CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                 "         "              "          "    CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                 "         "              "          "    CH.sub.2 CH(CH.sub.2 OC.sub.6                                                 H.sub.5)           "                 "         "              "          "    CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2           "                 "         "              "          "    CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2           "                 C.sub.6 H.sub.5                                                                         "              "          "    CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2 CH.sub.2  "                 "         "              "          "    CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                       "                 "         "              "          "    CH.sub.2 CH.sub.2 N(SO.sub.2                                                  C.sub.6 H.sub.5)CH.sub.2                                                                         "H.sub.2          "         "              "          "    CH.sub.2 CH.sub.2 SO.sub.2                                                    N(CH.sub.3)CH.sub.2 CH.sub.2                                                                     "                 "         "              "          "    CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                 "         "              "          "    CH.sub.2 CH.sub.2 CH.sub.2                                                    NHSO.sub.2 CH.sub.2 CH.sub.2                                                                     "                 "         "              "          "    CH.sub.2 CH.sub.2 CONHCH.sub.2                                                CH.sub.2           "                 "         "              "          "    CH.sub.2 CH.sub.2 CONHCH.sub.2                                                CH.sub.2 CH.sub.2                                                                                "H.sub.2          "         "              "          "    CH.sub.2 CH.sub.2 SO.sub.2                                                    N(C.sub.6 H.sub.5)CH.sub.2                                                    CH.sub.2           "                 "         "              "          "    CH.sub.2 CH.sub.2 NHCONHCH.sub.2                                              CH.sub.2           "                 "         "              "          "    CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                 "         "              "          "    CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2SCH.sub.2 CH.sub.2                                                                       "                 __________________________________________________________________________

                                      TABLE 19                                    __________________________________________________________________________     ##STR64##                                                                    Substituents on                                                               Ring G               (R.sub.1).sub.m                                                                         R.sub.2      Z               M                 __________________________________________________________________________    3,5-di-CN-4-CH.sub.3                                                                             None      C.sub.2 H.sub.5                                                                            CH.sub.2 CH.sub.2                                                                              K.sup.+            "                  "         C.sub.6 H.sub.11                                                                           "                "                  "                  "         C.sub.6 H.sub.5                                                                            "                "                  "                  3CH.sub.3 C.sub.2 H.sub.5                                                                            "                "                  3-CN-5-C.sub.6 H.sub.5                                                                           "         CH.sub.2 C.sub.6 H.sub.5                                                                   "                "                  3-COOCH.sub.3 -5-C.sub.6 H.sub.5                                                                 "         CH.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2         "                  3-CONH.sub.2 -5-C.sub.6 H.sub.5                                                                  "         CH.sub.2 CH.sub.2 CONH.sub.2                                                               CH.sub.2 CH.sub.2                                                                              "                  3-CONHC.sub.2 H.sub.5 -5-C.sub.6 H.sub.5                                                         "         CH.sub.2 CH.sub.2 Cl                                                                       "                "                  3-COOCH.sub.3      3-NHCOCH.sub.3                                                                          C.sub.2 H.sub.5                                                                            "                "                  3-CN               2-CH.sub.3 -5-NHCOCH.sub.3                                                              H            "                "                  3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                                            2-OCH.sub.3 -5-CH.sub.3                                                                 "            "                "                  "                  2-Cl      "            "                "                  "                  2-CH.sub.3                                                                              "            "                "                  "                  2,5-di-Cl "            "                "                  3-CN-4-CH.sub.3 -5-COCH.sub.3                                                                    2-OCH.sub.3 -5-Cl                                                                       "            "                "                  3-COOCH.sub.3 -4-CH.sub.3 -5-CN                                                                  2-OCH.sub.3 -5-CH.sub.3                                                                 "            "                "                  3-COOCH.sub.3 -4-CH.sub.3 -5-COC.sub.6 H.sub.5                                                   2,5-di-CH.sub.3                                                                         "            "                Na.sup.+           3-COOCH.sub.3 -5-COC.sub.6 H.sub.5                                                               3-CH.sub.3                                                                               ##STR65##   "                "                  3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                                            3-CH.sub.3                                                                               ##STR66##   CH.sub.2 CH(CH.sub.2 Cl)                                                                       "                  "                  3-CH.sub.3                                                                               ##STR67##   CH.sub.2 CH.sub.2                                                                              NH.sub.4.sup.+     "                  3-CH.sub.3                                                                               ##STR68##   "                K.sup.+            "                  3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 NHSO.sub.2 CH.sub.3                                                      "                "                  "                  3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 CH.sub.2 NHCOCH.sub.3                                                    "                "                  "                  None      CH.sub.3     CH.sub.2 CH.sub.2                                                                              "                  3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                                         3-CH.sub.3                                                                              CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2         "                  3-SO.sub.2 CH.sub.3 -5-CN                                                                        "         CH.sub.2 C.sub.6 H.sub.11                                                                  CH.sub.2 CH.sub.2                                                                              "                  3-SO.sub.2 C.sub.6 H.sub.5 -5-Br                                                                 "         CH.sub.2 CH.sub.2 OC.sub.6 H.sub.5                                                         "                "                  3,5-di-SO.sub.2 CH.sub.3                                                                         "         CH(CH.sub.3).sub.2                                                                         "                "                  3,5-di-SO.sub.2 NH.sub.2                                                                         H         CH.sub.2 CH.sub.3                                                                          "                K.sup.+            3,5-di-SO.sub.2 N(C.sub.2 H.sub.5).sub.2                                                         "         CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                          OC.sub.2 H.sub.5                                                                           "                "                  3-CN-5-COCH.sub.3  3-CH.sub.3                                                                              CH.sub.2 CH.sub.3                                                                          "                "                  3-CN-5-COOC(CH.sub.3).sub.2                                                                      "         "            "                "                  3-CN-5-COOC.sub.2 H.sub.5                                                                        "         "            "                "                  3-CONH.sub.2 -5-COOC.sub.2 H.sub.5                                                               "         "            "                "                  3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                                             3-NHCOC.sub.6 H.sub.5                                                                   "            "                "                  3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                                                  3-NHCONHC.sub.2 H.sub.5                                                                 "            "                "                  "                  3-NHCOCH.sub.2 OCH.sub.3                                                                "            "                "                  "                  3-NHCOC.sub.6 H.sub.11                                                                  "            "                "                  "                  3-NHCOOC.sub.2 H.sub.5                                                                  "            CH.sub.2 CH(CH.sub.3)                                                                          "                  "                  3-NHCOCH.sub.2 CN                                                                       "            CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                "                  3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                                          "         "            CH.sub. 2 CH.sub.2                                                                             "                  3-CONHC.sub.4 H.sub.9 -n-5-COCH(CH.sub.3).sub.2                                                  None      "            "                "                  3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                                                  "         "            "                "                  3-COOCH.sub.3 -5-SO.sub.2 CH.sub.3                                                               3-CH.sub.3                                                                              "            CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2         "                  3-CONHC.sub.2 H.sub.5 -5-SO.sub.2 CH.sub.3                                                       "         "            CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2 CH.sub.2 CH.sub.2                                                    CH.sub.2         "                  3-CONH.sub.2 -5-SO.sub.2 CH.sub.3                                                                "         "            CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                     "                  3-CONH.sub.2 -5-SO.sub.2 C.sub.4 H.sub.9 -n                                                      "         "            CH.sub.2 CH.sub.2 N(COCH.sub.3)C                                              H.sub.2 CH.sub.2 "                  3-COOCH.sub.3 -HCH.sub.3 -5-SCN                                                                  "         "            CH.sub.2 CH.sub.2 SO.sub.2                                                    NHCH.sub.2 CH.sub.2                                                                            "                  3-CHO-4-CH.sub.3   "         "            CH.sub.2 CH.sub.2                                                                              "                  3-CONH.sub.2 -5-C.sub.6 H.sub.4 -p-CH.sub.3                                                      "         "            "                "                  3-CN-5-COOC.sub.2 H.sub.5                                                                        "         "            CH.sub.2 CH.sub.2 CONHC.sub.2                                                 H.sub.4          "                  3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                                            "         "            CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                 "                  "                  "         "            CH.sub.2 CH.sub.2 NHSO.sub.2                                                  CH.sub.2 CH.sub.2                                                                              "                  "                  3-NHCOC.sub.6 H.sub.5                                                                   "            CH.sub.2 CH.sub.2                                                                              "                  "                  3-NHCOOC.sub.2 H.sub.5                                                                  "            "                "                  "                  3-CH.sub.3                                                                              CH.sub.2 CH.sub.2 OSO.sub.3 Na                                                             "                Na.sup.+           "                  "         C.sub.2 H.sub.5                                                                            CH.sub.2 CH(OSO.sub.3 Na)CH.sub.                                              2                "                  __________________________________________________________________________

                                      TABLE 20                                    __________________________________________________________________________     ##STR69##                                                                    Substituents on                                                                Ring G              (R.sub.1).sub.m                                                                        R.sub.3                                                                            R.sub.4                                                                               Z                M                 __________________________________________________________________________    3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                                                    None       CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 CH.sub.2  K.sup.+           "                  "          H   CH.sub.3                                                                             "                  "                 3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                                             7-CH.sub.3 "   "      "                  "                 "                  "          CH.sub.3                                                                          "      "                  "                 "                  7-CH.sub.3 H   CH(CH.sub.3).sub.2                                                                   "                  "                 "                  7-OCH.sub.3                                                                              "   CH.sub.3                                                                             "                  "                 "                  5-OCH.sub.3, 8-CH.sub.3                                                                  "   "      "                  "                 "                  5,8-di-OCH.sub.3                                                                         "   "      "                  "                 "                  5,8-di-CH.sub.3                                                                          "   "      "                  "                 "                  7-Cl       "   "      "                  "                 "                  5,8-di-Cl  "   "      "                  "                 3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                                            None       "   "      "                  Na.sup.+          "                  5-OCH.sub.3, 8-CH.sub.3                                                                  CH.sub.3                                                                          "      "                  "                 "                  7-NHCHO    "   "      "                  "                 "                  7-NHCOCH.sub.3                                                                           "   "      "                  "                 "                  7-NHCOCH.sub.2 OCH.sub.3                                                                 "   "      "                  "                 3,5-di-CN-4-CH.sub.3                                                                             7-NHCOOC.sub.2 H.sub.5                                                                   "   "      "                  "                 "                  7-NHCOC.sub.6 H.sub.5                                                                    "   "      "                  "                 "                  7-NHCONHC.sub.2 H.sub.5                                                                  "   "      "                  K.sup.+           "                  7-NHCOC.sub.6 H.sub.11                                                                   "   "      "                  "                 "                  None       "   "      "                  "                 3-CONH.sub.2 -5-C.sub.6 H.sub.5                                                                  7-CH.sub.3 H   "      "                  "                 "                  "          "   H      "                  "                 3-COOCH.sub.3 -5-C.sub.6 H.sub.5                                                                 "          "   CH.sub.3                                                                             "                  "                 3-COOCH.sub.3 -5-COCH.sub.3                                                                      "          "   "      "                  "                 3-CN-5-COOC.sub.2 H.sub.5                                                                        "          "   "      "                  "                 3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                                            "          "   "      "                  "                 3-CN-4-CH.sub.3 -5-COCH.sub.3                                                                    "          "   "      "                  "                 3-COOCH.sub.3 -4-CH.sub.3 -5-CN                                                                  7-OCH.sub.3                                                                              "   "      "                  "                 3-CN-4-CH.sub.3 -5-CO.sub.2 CH.sub.2 CH.sub.2 OC.sub.2 H.sub.5                                   7-CH.sub.3 "   "      "                  "                 3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                                         "          "   "      "                  "                 3-SO.sub.2 C.sub.6 H.sub.4 -p-Cl-5-COCH.sub.3                                                    "          "   "      "                  "                 3-SO.sub.2 CH.sub.3 -5-CN                                                                        "          "   "      "                  "                 3-COOCH.sub.3 -5-Br                                                                              "          "   "      "                  "                 3-COOCH.sub.3 -5-SCN                                                                             "          "   "      "                  "                 3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                                                  None       "   "      "                  "                 3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                                          "          "   "      "                  "                 3-CN-5-SO.sub.2 CH.sub.3                                                                         "          "   "      "                  "                 3,5-di-SO.sub.2 NH.sub.2                                                                         "          "   "      "                  "                 3,5-di-SO.sub.2 NHC.sub.2 H.sub.5                                                                7-CH.sub.3 "   "      "                  "                 3-COOCH.sub.3 -5-COC.sub.6 H.sub.5                                                               "          "   "      "                  "                 3-CONHC.sub.4 H.sub.9 -n-5-COC.sub.6 H.sub.5                                                     "          "   "      CH.sub.2 CH.sub.2 OCH.sub.2                                                   CH.sub.2           "                 3-COOCH.sub.3 -5-SO.sub.2 CH.sub.3                                                               "          "   "      CH.sub.2 CH.sub.2 SCH.sub.2                                                   CH.sub.2           "                 3-CONHC.sub.2 H.sub.4 OH-5-SO.sub.2 CH.sub.3                                                     "          "   "      CH.sub.2 CH.sub.2 SO.sub.2                                                    CH.sub.2 CH.sub.2  "                 3-CHO              "          "   "      CH.sub.2 CH.sub.2 N(SO.sub.2                                                  CH.sub.3)CH.sub.2 CH.sub.2                                                                       "                 3-SO.sub.2 C.sub.6 H.sub.5                                                                       "          "   "      CH.sub.2 CH.sub.2 SO.sub.2                                                    NHCH.sub.2 CH.sub.2                                                                              "                 3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                                                    "          "   "      CH.sub.2 CH.sub.2 CH.sub.2                                                    NHCOCH.sub.2       "                 "                  "          "   "      CH.sub.2 CH.sub.2 CONHCH.sub.2                                                CH.sub.2           "                 "                  "          "   "      CH.sub.2 CH.sub.2 N(COC.sub.6                                                 H.sub.5)CH.sub.2 CH.sub.2                                                                        "                 "                  "          "   "      CH.sub.2 CH.sub.2 (CH.sub.3)                                                                     "                 "                  "          "   "      CH.sub.2 CH(OSO.sub.3 Na)CH.sub.2                                                                Na.sup.+          "                  "          "   "      CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                 "                  "          "   "      CH.sub.2 CH(CH.sub.2 OCH.sub.3)                                                                  "                 "                  "          "   "      CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                 "                  "          "   "      CH.sub.2 CH(CH.sub.2 OC.sub.6                                                 H.sub.5)           "                 3-COOCH.sub.3 -4CH.sub.3 -5-CONH.sub.2                                                           "          "   "      CH.sub.2 CH.sub.2 CH.sub.2                                                    N(CH.sub.3)SO.sub.2 CH.sub.2                                                  CH.sub.2           "                 "                  "          "   "      CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                 __________________________________________________________________________

                                      TABLE 21                                    __________________________________________________________________________     ##STR70##                                                                    Substituents on                                                               Ring G             (R.sub.1).sub.m                                                                         R.sub.3                                                                           Z                  M                         __________________________________________________________________________    3-COOCH.sub.3 -5-COCH(CH.sub.3).sub.2                                                            None      H   CH.sub.2 CH.sub.2  Na.sup.+                  3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                                             6-CH.sub.3                                                                              "   "                  "                         3-CN-5-COCH(CH.sub.3).sub.2                                                                      "         3-CH.sub.3                                                                        "                  "                         "                  6-OCH.sub.3                                                                             "   "                  "                         3-CONH.sub.2 -5-C.sub.6 H.sub.5                                                                  "         H   "                  "                         "                  6-CH.sub.3                                                                              3-CH.sub.3                                                                        CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2                                                              "                         "                  "         "   CH.sub.2 CH.sub.2  "                         3-CN-5-C.sub.6 H.sub.5                                                                           "         "   "                  "                         3-CONHC.sub.2 H.sub.4 OHOH-5-C.sub.6 H.sub.5                                                     "         "   "                  "                         3-CONHC.sub.2 H.sub.5 -5-COC.sub.6 H.sub.5                                                       "         "   "                  "                         3-CONHCH.sub.3 -5-COC.sub.6 H.sub.5                                                              "         "   "                  "                         3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.5                                                            "         "   "                  "                         3-CN-4-CH.sub.3 -5-COOC.sub.2 H.sub.4 OCH.sub.3                                                  "         "   "                  "                         3-CHO-4,5-di-CH.sub. 3                                                                           "         "   "                  "                         3-CN-4-CH.sub.3 -5-SCH.sub.3                                                                     6-NHCOCH.sub.3                                                                          "   "                  K.sup.+                   3-COOCH.sub.3 -4-CH.sub.3 -5-CONH.sub.2                                                          6-NHCOC.sub.6 H.sub.5                                                                   "   "                  "                         3-CONH.sub.2 -4-CH.sub.3 -5-CN                                                                   6-NHCOC.sub.4 H.sub.9 -n                                                                "   "                  "                         3,5-di-CN-4-CH.sub. 3                                                                            6-NHCONHC.sub.2 H.sub.5                                                                 "   "                  "                         "                  6-NHCOCH.sub.2 OCH.sub.3                                                                "   "                  "                         "                  6-NHCOCH.sub.2 CN                                                                       "   "                  "                         "                  6-CH.sub.3                                                                              "   "                  Na.sup. +                 3-CONH.sub.2 -4-CH.sub.3 -5-COOCH.sub.3                                                          "         "   "                  "                         3-SO.sub.2 CH.sub.3 -5-COCH.sub.3                                                                "         "   "                  "                         3-SO.sub.2 C.sub.6 H.sub.5 -5-COCH.sub.3                                                         "         "   "                  "                         3-SO.sub.2 C.sub.6 H.sub.4 -p-Cl-5-COCH.sub. 3                                                   "         "   "                  "                         3-SO.sub.2 CH.sub.3 -5-Br                                                                        "         "   "                  "                         3,5-di-SO.sub.2 CH.sub.3                                                                         "         "   "                  "                         3,5-di-SO.sub.2 NH.sub.2                                                                         "         "   "                  "                         3,5-di-SO.sub.2 NHC.sub.2 H.sub.5                                                                "         "   "                  "                         3-CONHC.sub.2 H.sub.4 OH-5-COCH(CH.sub.3).sub.2                                                  6-NHCHO   "   "                  "                         3-CONHC.sub.3 H.sub.6 OCH.sub.3 -5-COCH(CH.sub.3).sub.2                                          6-CH.sub.3                                                                              "   "                  "                         3-CONHC.sub.2 H.sub.4 NHCOCH.sub.3                                                               "         "   "                  "                         3-CONHC.sub.4 H.sub.9 -n-5-C.sub.6 H.sub.5                                                       "         "   "                  "                         3-CN-5-COOC.sub.2 H.sub.5                                                                        "         "   "                  "                         3-CN-4-CH.sub.3 -5-COOCH(CH.sub.3).sub.2                                                         "         "   "                  "                         3-CN-4-CH.sub.3SCONHC.sub.2 H.sub.5                                                              "         "   "                  "                         3-CN-4-CH.sub.3 -5-CONHC.sub.6 H.sub.5                                                           "         "   "                  "                         3-CONH.sub.2 -5-SO.sub.2 CH.sub.3                                                                "         "   "                  "                         3-CONH.sub.2 -5-COCH(CH.sub.3).sub.2                                                             "         "   CH.sub.2 CH(CH.sub.3)                                                                            "                         "                  "         "   CH.sub.2 CH(C.sub.6 H.sub.5)                                                                     "                         "                  "         "   CH.sub.2 CH(CH.sub.2 Cl)                                                                         "                         "                  "         "   CH.sub.2 CH(OSO.sub.3 K)CH.sub.2                                                                 "                         "                  "         "   CH.sub.2 CH(CH.sub.2 OC.sub.6 H.sub.5)                                                           "                         "                  "         "   CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2                                                             "                         3-CONHC.sub.2 H.sub.5 -5-COCH(CH.sub.3).sub.2                                                    "         "   CH.sub.2 CH.sub.2 SCH.sub.2 CH.sub.2                                                             "                         "                  "         "   CH.sub.2 CH.sub.2 SO.sub.2 CH.sub.2                                           CH.sub.2           "                         "                  "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 CH.sub.3)CH.                                     sub.2 CH.sub.2     "                         "                  "         "   CH.sub.2 CH.sub.2 N(SO.sub.2 C.sub.6                                          H.sub.5)CH.sub.2 CH.sub.2                                                                        "                         "                  "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(CH.sub.3)CH.                                     sub.2 CH.sub.2     "                         "                  "         "   CH.sub.2 CH.sub.2 NHCOCH.sub.2                                                                   "                         "                  "         "   CH.sub.2 CH.sub.2 CH.sub.2 NHSO.sub.2                                         CH.sub.2 CH.sub.2  "                         "                  "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                                          "                         "                  "         "   CH.sub.2 CH.sub.2 CONHCH.sub.2 CH.sub.2                                       CH.sub.2 CH.sub.2  "                         "                  "         "   CH.sub.2 CH.sub.2 SO.sub.2 N(C.sub.6                                          H.sub.5)CH.sub.2 CH.sub.2                                                                        "                         "                  "         "   CH.sub.2 CH.sub.2 NHCONHCH.sub.2                                                                 "H.sub.2                  "                  "         "   CH.sub.2 CH.sub.2 CH.sub.2                                                                       "                         "                  "         "   CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2SCH.su                                     b.2 CH.sub.2       "                         __________________________________________________________________________

Although the invention has been described in considerable detail withparticular reference to certain preferred embodiments thereof,variations and modifications can be effected within the spirit and scopeof the invention.

We claim:
 1. A compound of the formula

    R--N═N--C

wherein R is selected from benzothiazol-2-yl which may have 1-3substituents selected from lower alkyl, lower alkoxy, thiocyano, loweralkylthio, cyano, carbamoyl, lower alkylcarbamoyl, lower alkoxycarbonyl,acyl, lower alkylsulfonyl, sulfamoyl, SO₂ NH(lower alkyl), SO₂N(di-lower alkyl), lower alkylsulfonamido, acylamido, halogen,trifluoromethyl and SO₃ (aryl); 2,1-benzisothiazol-3-yl which may have1-3 substituents selected from lower alkyl, lower alkoxy, chlorine,bromine, SO₂ NH₂, SO₂ NH(lower alkyl), and SO₂ N(di-lower alkyl);1,3,4-thiadiazol-2-yl which may have a substituent selected from loweralkyl, lower alkoxy, halogen, lower alkylsulfonyl, SO₂ NH₂, SO₂ NH(loweralkyl), SO₂ N (di-lower alkyl), arylsulfonyl, acylamido, aryl, arylthio,lower alkenylthio, cyclohexylthio, thiocyano, cyclohexylsulfonyl, loweralkylthio, and cyclohexyl; 1,2,4-thiadiazol-5-yl which may have asubstituent selected from lower alkyl, aryl, lower alkylthio,cyclohexylthio, and lower alkylsulfonyl; isothiazol-5-yl which may have1 or 2 substituents selected from lower alkyl, halogen, cyano,carbamoyl, CONH lower alkyl, alkoxycarbonyl, lower alkylthio, loweralkenylthio, arylthio, cyclohexylthio, s-heterocycle, aryloxy, and loweralkoxy; pyrazol-5-yl which may have 1 or 2 substituents selected fromlower alkyl, lower alkoxycarbonyl, lower alkylthio, aryl, cyano,carbamoyl, lower alkylcarbamoyl, and lower alkylsulfonyl, and thehydrogen on the N may be replaced with lower alkyl, aryl of 6-10carbons, lower alkylsulfonyl, arylsulfonyl, lower alkanoyl, or loweralkoxycarbonyl; and thiophen-2-yl which may be substituted with 1-3groups selected from lower alkyl, cyano, lower alkoxycarbonyl, acyl,lower alkylsulfonyl, arylsulfonyl, carbamoyl, lower alkylcarbamoyl,aryl, halogen, sulfamoyl, lower alkylsulfamoyl and formyl; and thecoupler C is selected from those of the formulae: ##STR71## wherein R₁is selected from hydrogen, lower alkyl, lower alkoxy, halogen,acylamido, lower alkylthio, and aryloxy; R₂ is selected from hydrogen,aryl, cycloalkyl, lower alkenyl and lower alkyl; R₃ and R₄ are eachselected from hydrogen and lower alkyl; m is 0, 1 or 2; M is Na⁺, K⁺, H⁺or NH₄ ⁺ ; Z is selected from straight or branched chain lower alkyleneand divalent groups of the formula --CH₂ (CH₂)_(n) X--CH₂ (CH₂)_(p) --,where n is 1, 2 or 3, p is 0, 1, 2 or 3, and X is O, S, SO₂, --SO₂ NH--,--SO₂ N(lower alkyl)--, --N(SO₂ lower alkyl)--, --N(SO₂ aryl)--,--NHCO--, --NHCONH--, and --CON(lower alkyl); and in the abovedefinition of X, Z, R, R₁, and R₂, any lower alkyl, lower alkylene, orcyclic radicals may bear up to three substituents selected from hydroxy,lower alkoxy, aryl, aryloxy, cyclohexyl, furyl, lower alkylcyclohexyl,aroyloxy, lower alkoxycarbonyl, lower alkanoyloxy, sulfamoyl, SO₂NH(aryl), SO₂ NH(lower alkyl), SO₂ N(di-lower alkyl), NHCOO(loweralkyl), NHCONH(lower alkyl), acylamido, lower alkylsulfonamido,succinimido, glutarimido, phthalimido, 2-pyrrolidono, cyano, carbamoyl,lower alkylcarbamoyl, lower alkoxyalkoxy, lower alkylthio, halogen,arylthio, lower alkylsulfonyl and arylsulfonyl.
 2. A compound accordingto claim 1 wherein the diazo is benzothiazol-2-yl as defined therein,and the coupler has the formula ##STR72## as defined therein.
 3. Acompound according to claim 1 wherein the diazo is2,1-benzisothiazol-3-yl as defined therein, and the coupler has theformula ##STR73## as defined therein.
 4. A compound according to claim 1wherein the diazo is 1,3,4-thiadiazol-2-yl as defined therein, and thecoupler has the formula ##STR74## as defined therein.
 5. A compoundaccording to claim 1 wherein the diazo is 1,2,4-thiadiazol-5-yl asdefined therein, and the coupler has the formula ##STR75## as definedtherein.
 6. A compound according to claim 1 wherein the diazo isisothiazol-5-yl as defined therein, and the coupler has the formula##STR76## as defined therein.
 7. A compound according to claim 1 whereinthe diazo is pyrazol-5-yl as defined therein, and the coupler has theformula ##STR77## as defined therein.
 8. A compound according to claim 1wherein the diazo is thiophen-2-yl as defined therein, and the couplerhas the formula ##STR78## as defined therein.
 9. A compound according toclaim 1 wherein the diazo is benzothiazol-2-yl as defined therein, andthe coupler has the formula ##STR79## as defined therein.
 10. A compoundaccording to claim 1 wherein the diazo is 2,1-benzisothiazol-3-yl asdefined therein, and the coupler has the formula ##STR80## as definedtherein.
 11. A compound according to claim 1 wherein the diazo is1,3,4-thiadiazol-2-yl as defined therein, and the coupler has theformula ##STR81## as defined therein.
 12. A compound according to claim1 wherein the diazo is 1,2,4-thiadiazol-5-yl as defined therein, and thecoupler has the formula ##STR82## as defined therein.
 13. A compoundaccording to claim 1 wherein the diazo is isothiazol-5-yl as definedtherein, and the coupler has the formula ##STR83## as defined therein.14. A compound according to claim 1 wherein the diazo is pyrazol-5-yl asdefined therein, and the coupler has the formula ##STR84## as definedtherein.
 15. A compound according to claim 1 wherein the diazo isthiophen-2-yl as defined therein, and the coupler has the formula##STR85## as defined therein.
 16. A compound according to claim 1wherein the diazo is benzothiazol-2-yl as defined therein, and thecoupler has the formula ##STR86## as defined therein.
 17. A compoundaccording to claim 1 wherein the diazo is 2,1-benzisothiazol-3-yl asdefined therein, and the coupler has the formula ##STR87## as definedtherein.
 18. A compound according to claim 1 wherein the diazo is1,3,4-thiadiazol-2-yl as defined therein, and the coupler has theformula ##STR88## as defined therein.
 19. A compound according to claim1 wherein the diazo is 1,2,4-thiadiazol-5-yl as defined therein, and thecoupler has the formula ##STR89## as defined therein.
 20. A compoundaccording to claim 1 wherein the diazo is isothiazol-5-yl as definedtherein, and the coupler has the formula ##STR90## as defined therein.21. A compound according to claim 1 wherein the diazo is pyrazol-5-yl asdefined therein, and the coupler has the formula ##STR91## as definedtherein.
 22. A compound according to claim 1 wherein the diazo isthiophen-2-yl as defined therein, and the coupler has the formula##STR92## as defined therein.
 23. The dye of claim 1 having the formula##STR93##
 24. The dye of claim 1 having the formula ##STR94##
 25. Thedye of claim 1 having the formula ##STR95##
 26. The dye of claim 1having the formula ##STR96##
 27. The dye of claim 1 having the formula##STR97##
 28. The dye of claim 1 having the formula ##STR98##
 29. Thedye of claim 1 having the formula ##STR99##
 30. The dye of claim 1having the formula ##STR100##
 31. The dye of claim 1 having the formula##STR101##
 32. The dye of claim 1 having the formula ##STR102##